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Table 1 Routine and specialised haemostatic parameters by experimental group at selected time points

From: Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support

  Ventilation only S-ALI control ECMO control S-ALI + ECMO
B 24 h B 24 h B 24 h B 24 h
Full blood examination
 WCC, ×109/L 9.8 (3.1) 10.2 (2.2) 7.8 (2.1) 21.8 (8.3)a 7.0 (2.2) 7.9 (1.7)a 6.6 (1.2) 9.1 (3.8)a
 RCC, ×1012/L 8.7 (0.68) 6.2 (0.6) 8.5 (0.78) 8.9 (1.36)a 8.0 (1.2) 4.8 (0.54)a 8.3 (0.87) 7.3 (1.2)
 Hb, g/L 97.8 (9.1) 70.3 (6.1) 96.1 (9.4) 99.1 (12)a 89.3 (12) 54.3 (5.4)a 93.4 (11) 83.5 (12)
 Hct 0.28 (0.02) 0.20 (0.02) 0.28 (0.03) 0.29 (0.04)a 0.26 (0.04) 0.16 (0.01)a 0.28 (0.03) 0.24 (0.04)
 PLT, ×109/L 341 (173) 190 (110) 355 (186) 203 (111) 471 (95) 260 (80) 364 (140) 199 (60)
Routine coagulation tests
 PT, seconds 14.5 (1) 17.3 (1) 15.9 (1.1) 34.4 (5.4)a 12.9 (0.6) 17.4 (2.1) 14.3 (0.9) 35 (6.7)a
 aPTT, seconds 33 (6) 139 (76) 31 (6) 165 (42) 26 (4.6) 122 (64) 30 (6) 158 (57)
 Fibrinogen, g/L 2.5 (0.54) 3.5 (0.13) 2.1 (0.62) 2.5 (0.34)a 2.9 (0.47) 2.6 (0.16)a 3.0 (0.97) 1.5 (0.5)a
d-dimer, ng/ml 215 (85) 198 (70) 146 (44) 139 (82) 435 (192) 343 (217) 406 (213) 213 (136)
 TCT, seconds 13 (0) 21 (7) 13 (0) 81 (84) 12 (1) 156 (81) 13 (1) 44 (69)
Specialised coagulation tests
 FVIII, % 1531 (413) 1390 (414) 1347 (417) 1544 (238) 891(235) 408 (51)a 904 (166) 531 (242)a
 FXII, % 103 (17.7) 75 (10) 96 (30.9) 29 (11.5)a 151 (37.7) 67 (12.4) 107 (20.2) 16 (6.7)a
 Protein C, % 21.5 (2.5) 21.5 (1.3) 21 (7.4) 12.1 (3.2) 55 (13.4) 50 (11.2) 46 (11.4) 14 (4.5)a
 vWAg, % 136 (22.3) 130 (25.8) 96 (31.9) 140 (18.2) 94 (47.6) 88 (10.9)a 129 (30) 96 (25.3)a
 AT, % 85.8 (7.3) 58.3 (6.6) 84.1 (3.9) 27.1 (3.2)a 93.7 (8.8) 62.7 (6) 92.3 (1.9) 22 (4.3)a
  1. Abbreviations: aPTT Activated partial thromboplastin time, AT Anti-thrombin, B baseline, ECMO Extracorporeal membrane oxygenation, FVIII Factor VIII, FXII Factor XII, Hb Haemoglobin, Hct Haematocrit, PLT Platelets, PT Prothrombin time, RCC Red cell count, S-ALI Smoke-induced acute lung injury, TCT Thrombin clotting time, vWAg von Willebrand factor antigen, WCC White cell count
  2. Data are presented as mean (±SD)
  3. a P < 0.05 over time vs ventilation only