TY - JOUR AU - Gunst, Jan PY - 2017 DA - 2017/08/07 TI - Recovery from critical illness-induced organ failure: the role of autophagy JO - Critical Care SP - 209 VL - 21 IS - 1 AB - Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in the acute phase of critical illness activates autophagy and enhances recovery. Several registered drugs have autophagy-stimulating properties, but all lack specificity and none has been investigated in critically ill patients for this purpose. SN - 1364-8535 UR - https://doi.org/10.1186/s13054-017-1786-y DO - 10.1186/s13054-017-1786-y ID - Gunst2017 ER -