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Table 1 Historical comparison between outcomes after 7 h of sepsis in young (1–4 months) and old (22 months) mice, based on our published data in young mice and the present study in aged mice

From: Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

Septic outcome Young Old
Control Septic Control Septic
Feces dose (g/kg) - 3.75 [26] - 3.75
Lactate (mM) 0.7 ± 0.3 n = 6 [26] 2.1 ± 0.4 n = 6 [26] 0.49 ± 0.09 n = 8 1.87 ± 0.26 n = 6
Peritoneal fluid bacterial count (CFU) 0.30 ± 0.26 n = 13 [33] 44,520 ± 19,060 n = 15 [33] 1.6 ± 1.6 n = 9 32,066 ± 14,791 n = 7
Lung MPO (U/mL/mg) 0.16 ± 0.03 n = 10 [33] 0.41 ± 0.07 n = 9 [33] 1.66 ± 0.43 n = 6 4.28 ± 0.33 n = 6
Liver MPO (U/mL/mg) 0.023 ± 0.005 n = 6 [33] 0.071 ± 0.009 n = 6 [33] 0.35 ± 0.04 n = 6 0.60 ± 0.04 n = 6
Capillary plugging (%) 7.7 ± 0.6 n = 18 [27] 41.0 ± 1.5 n = 16 [27] 9.1 ± 1.0 n = 9 80.0 ± 8.8 n = 7
  1. Data are presented as mean ± SE. Data for young mice are from our previous publications as indicated (Tyml et al., [26]; Swarbreck et al., [33]; Secor et al., [27]). Data for old mice lung and liver myeloperoxidase (MPO) and capillary plugging are from Figs. 1a, 4 and 5b, respectively.