Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice

Table 1 Historical comparison between outcomes after 7 h of sepsis in young (1–4 months) and old (22 months) mice, based on our published data in young mice and the present study in aged mice

Septic outcome	Young		Old
Septic outcome	Control	Septic	Control	Septic
Feces dose (g/kg)	-	3.75 [26]	-	3.75
Lactate (mM)	0.7 ± 0.3 n = 6 [26]	2.1 ± 0.4 n = 6 [26]	0.49 ± 0.09 n = 8	1.87 ± 0.26 n = 6
Peritoneal fluid bacterial count (CFU)	0.30 ± 0.26 n = 13 [33]	44,520 ± 19,060 n = 15 [33]	1.6 ± 1.6 n = 9	32,066 ± 14,791 n = 7
Lung MPO (U/mL/mg)	0.16 ± 0.03 n = 10 [33]	0.41 ± 0.07 n = 9 [33]	1.66 ± 0.43 n = 6	4.28 ± 0.33 n = 6
Liver MPO (U/mL/mg)	0.023 ± 0.005 n = 6 [33]	0.071 ± 0.009 n = 6 [33]	0.35 ± 0.04 n = 6	0.60 ± 0.04 n = 6
Capillary plugging (%)	7.7 ± 0.6 n = 18 [27]	41.0 ± 1.5 n = 16 [27]	9.1 ± 1.0 n = 9	80.0 ± 8.8 n = 7

Data are presented as mean ± SE. Data for young mice are from our previous publications as indicated (Tyml et al., [26]; Swarbreck et al., [33]; Secor et al., [27]). Data for old mice lung and liver myeloperoxidase (MPO) and capillary plugging are from Figs. 1a, 4 and 5b, respectively.

ISSN: 1364-8535