Table 1 Main characteristic of the seven included studies
StudyID | Study type | Number (DEX/Control) | Surgery type | Intervention | Ref (DOI) | |
|---|---|---|---|---|---|---|
DEX | Control | |||||
Ammar et al. 2016 [4] | RCT | 25/25 | Cardiac surgery with CPB | 5 min before CPB until 6 h after surgery (1 μg/kg for 15 min and followed by 0.5 μg/kg/h) | Placebo | |
Balkanay et al. 2015 [2] | RCT | 60/28 | CABG with CPB | After ICU admission and continuing for a maximum of 24 h (0.04 μg/kg/h to 0.5 μg/kg/h) | Placebo | |
Cho et al. 2015 [5] | RCT | 100/100 | Cardiac surgery with CPB | After anesthetic induction and continuing for 24 h after surgery (0.4 μg/kg/h) | Placebo | |
Ji et al. 2013 [3] | Cohort (retrospective) | 567/566 | CABG/valve surgery with CPB | After CPB and continuing for a maximum of 24 h (0.24 μg/kg/h to 0.6 μg/kg/h) | Control | |
Kwiatkowski et al. 2016 | Cohort (retrospective) | 102/102 | Cardiac surgery with CPB | NR | Control | |
Shehabi et al. 2012 | Cohort (prospective) | 76/77 | Cardiac surgery with CPB | After anesthetic induction and until extubation (0.7 μg/kg/h) | Control | |
Turan et al. 2014 | Cohort (retrospective) | 765/17,011 | Cardiac surgery | NR | Control | |