Table 4 Antibiotic and clinical outcomes
Enhanced antibiotic de-escalation (n = 144) | Routine antibiotic management (n = 139) | P value | |
|---|---|---|---|
Early failure of initial antibiotics | 40 (27.8) | 33 (23.7) | 0.438 |
Antibiotics de-escalated* | 70/104 (67.3) | 70/106 (66.0) | 0.845 |
Deterioration post de-escalation* | 8/70 (11.4) | 6/70 (8.6) | 0.573 |
Total antibiotic days | 7.0 (4.0, 8.8) | 7.0 (4.0, 9.0) | 0.616 |
Mortality | 51 (35.4) | 35 (25.2) | 0.061 |
ICU length of stay | 6.0 (3.0, 12.0) | 6.0 (4.0, 12.0) | 0.935 |
Hospital length of stay | 11.0 (6.0, 22.0) | 12.0 (6.0, 20) | 0.918 |
Ventilator days | 4.5 (2.0, 9.0) | 4.0 (2.0, 9.0) | 0.953 |
Secondary pneumonia | 12 (8.3) | 12 (8.6) | 0.928 |
Secondary pneumonia due to antibiotic-resistant pathogen | 9 (6.3) | 6 (4.3) | 0.468 |