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Table 3 Patients’ demographic data and clinical characteristics grouped according to baseline DHEAS/cortisol ratio

From: Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?

 

High DHEAS/cortisol ratio (>1.50) (n = 17)

Low DHEAS/cortisol ratio (<1.50) (n = 29)

p value

Age (years)

48.7 ± 11.4

60.2 ± 15.2

0.010

Gender (M/F)

15/2

21/8

0.282

Hospital mortality

6/17 (35.3%)

28/29 (96.6%)

<0.001

SOFA score

10.8 ± 4.5

13.6 ± 3.7

0.030

MELD score

26.1 ± 12.7

32.1 ± 10.0

0.082

Child–Pugh score

12 (8–12.5)

12 (11–13.5)

0.106

ACTH (pg/ml)

19 (7.8–27.2)

20.4 (10.8–38)

0.372

Baseline cortisol (nmol/L)

441 (382–691)

910 (661–1422)

0.001

Peak cortisol (nmol/L)

822 (608–1141)

1048 (902–1671)

0.006

Cortisol increment (nmol/L)

273 (189–403)

196 (97–288)

0.037

Baseline DHEAS (nmol/L)

1099 (885–2124)

551 (362–769)

<0.001

Peak DHEAS (nmol/L)

1286 (974–2546)

643 (360–1057)

<0.001

DHEAS increment (nmol/L)

135.7 (88.2–248.3)

35.3 (6.8–118.1)

0.009

IL-6 (pg/ml)

198 (58.5–444)

571 (221–1012)

0.025

TNF-α (pg/ml)

17.6 (8.4–32.3)

47.5 (30–96.8)

0.002

CIRCI

7/17 (41.2%)

21/29 (72.4%)

0.036

  1. Data presented as mean ± SD, number (percentage), or median (interquartile range)
  2. M male, F female, SOFA Sequential Organ Failure Assessment, MELD Model for End-Stage Liver Disease, ACTH adrenocorticotropic hormone, DHEAS dehydroepiandrosterone sulfate, IL-6 interleukin-6, TNF-α tumor necrosis factor alpha, CIRCI critical illness-related corticosteroid deficiency