| High DHEAS/cortisol ratio (>1.50) (n = 17) | Low DHEAS/cortisol ratio (<1.50) (n = 29) | p value |
---|---|---|---|
Age (years) | 48.7 ± 11.4 | 60.2 ± 15.2 | 0.010 |
Gender (M/F) | 15/2 | 21/8 | 0.282 |
Hospital mortality | 6/17 (35.3%) | 28/29 (96.6%) | <0.001 |
SOFA score | 10.8 ± 4.5 | 13.6 ± 3.7 | 0.030 |
MELD score | 26.1 ± 12.7 | 32.1 ± 10.0 | 0.082 |
Child–Pugh score | 12 (8–12.5) | 12 (11–13.5) | 0.106 |
ACTH (pg/ml) | 19 (7.8–27.2) | 20.4 (10.8–38) | 0.372 |
Baseline cortisol (nmol/L) | 441 (382–691) | 910 (661–1422) | 0.001 |
Peak cortisol (nmol/L) | 822 (608–1141) | 1048 (902–1671) | 0.006 |
Cortisol increment (nmol/L) | 273 (189–403) | 196 (97–288) | 0.037 |
Baseline DHEAS (nmol/L) | 1099 (885–2124) | 551 (362–769) | <0.001 |
Peak DHEAS (nmol/L) | 1286 (974–2546) | 643 (360–1057) | <0.001 |
DHEAS increment (nmol/L) | 135.7 (88.2–248.3) | 35.3 (6.8–118.1) | 0.009 |
IL-6 (pg/ml) | 198 (58.5–444) | 571 (221–1012) | 0.025 |
TNF-α (pg/ml) | 17.6 (8.4–32.3) | 47.5 (30–96.8) | 0.002 |
CIRCI | 7/17 (41.2%) | 21/29 (72.4%) | 0.036 |