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Table 1 Patients’ demographic data and clinical characteristics at admission to the ICU grouped according to hospital mortality

From: Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?

 

Hospital survivors (n = 12)

Hospital nonsurvivors (n = 34)

p value

Age (years)

47.6 ± 14.8

58.8 ± 14.3

0.029

Gender (M/F)

11/1

25/9

0.252

SOFA score

8.3 ± 2.5

14.0 ± 3.6

<0.001

MELD score

20.9 ± 10.7

33.0 ± 9.9

0.001

Child–Pugh score

10 (7.3–11.8)

12 (11–13.3)

0.005

ACTH (pg/ml)

8.7 (7.5–25.5)

20.7 (13.1–35.1)

0.084

Baseline cortisol (nmol/L)

484 (381–796)

821 (508–1312)

0.026

Peak cortisol (nmol/L)

955 (633–1258)

993 (807–1549)

0.354

Cortisol increment (nmol/L)

359 (257–428)

200 (110–252)

0.011

Baseline DHEAS (nmol/L)

1099 (787–2627)

622 (403–1006)

0.002

Peak DHEAS (nmol/L)

1286 (1118–2874)

699 (429–1115)

<0.001

DHEAS increment (nmol/L)

236 (179–391)

41 (10–96)

<0.001

Baseline DHEAS/cortisol ratio

2.86 ± 1.40

0.92 ± 0.73

0.001

IL-6 (pg/ml)

110 (54–233)

571 (247.25–924)

0.004

TNF-α (pg/ml)

10 (5.5–25)

45.5 (31.25–78.25)

0.001

  1. Data presented as mean ± SD, number, or median (interquartile range)
  2. M male, F female, SOFA Sequential Organ Failure Assessment, MELD Model for End-Stage Liver Disease, ACTH adrenocorticotropic hormone, DHEAS dehydroepiandrosterone sulfate, IL-6 interleukin-6, TNF-α tumor necrosis factor alpha, ICU intensive care unit