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Table 2 Sensitivity, specificity, PPV, NPV, LR+, and LR– of BDG and PCT used separately for the diagnosis of candidaemia over bacteraemia in the study population

From: Combined use of serum (1,3)-β-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units

 

No./total patients

      

Cut-off

Candidaemia (TP/total)

Bacteraemia (TN/total)

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

LR+

LR–

BDG

 ≥80 pg/ml

67/73

75/93

92

81

79

93

4.74

0.10

 ≥100 pg/ml

65/73

76/93

89

82

79

90

4.87

0.13

 ≥113 pg/ml

65/73

78/93

89

84

81

91

5.52

0.13

 ≥120 pg/ml

65/73

78/93

89

84

81

91

5.52

0.13

 ≥140 pg/ml

60/73

82/93

82

88

85

86

6.95

0.20

 ≥160 pg/ml

60/73

83/93

82

89

86

86

7.64

0.20

 ≥180 pg/ml

57/73

85/93

78

91

88

84

9.08

0.24

 ≥200 pg/ml

55/73

88/93

75

95

92

83

14.01

0.26

PCT

 <0.50 ng/ml

30/73

80/93

41

86

70

65

2.94

0.68

 <1.00 ng/ml

46/73

75/93

63

81

72

74

3.26

0.46

 <1.93 ng/ml

61/73

64/93

84

69

68

84

2.68

0.24

 <2.00 ng/ml

61/73

62/93

84

67

66

84

2.51

0.25

 <3.00 ng/ml

63/73

54/93

86

58

62

84

2.06

0.24

 <4.00 ng/ml

67/73

49/93

92

53

60

89

1.94

0.16

 <5.00 ng/ml

69/73

43/93

95

46

58

91

1.76

0.12

  1. BDG (1,3)-β-d-glucan, LR+ positive likelihood ratio, LR– negative likelihood ratio, NPV negative predictive value, PCT procalcitonin, PPV positive predictive value, TN true negatives, TP true positives