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Table 2 Sensitivity, specificity, PPV, NPV, LR+, and LR– of BDG and PCT used separately for the diagnosis of candidaemia over bacteraemia in the study population

From: Combined use of serum (1,3)-β-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units

  No./total patients       
Cut-off Candidaemia (TP/total) Bacteraemia (TN/total) Sensitivity (%) Specificity (%) PPV (%) NPV (%) LR+ LR–
BDG
 ≥80 pg/ml 67/73 75/93 92 81 79 93 4.74 0.10
 ≥100 pg/ml 65/73 76/93 89 82 79 90 4.87 0.13
 ≥113 pg/ml 65/73 78/93 89 84 81 91 5.52 0.13
 ≥120 pg/ml 65/73 78/93 89 84 81 91 5.52 0.13
 ≥140 pg/ml 60/73 82/93 82 88 85 86 6.95 0.20
 ≥160 pg/ml 60/73 83/93 82 89 86 86 7.64 0.20
 ≥180 pg/ml 57/73 85/93 78 91 88 84 9.08 0.24
 ≥200 pg/ml 55/73 88/93 75 95 92 83 14.01 0.26
PCT
 <0.50 ng/ml 30/73 80/93 41 86 70 65 2.94 0.68
 <1.00 ng/ml 46/73 75/93 63 81 72 74 3.26 0.46
 <1.93 ng/ml 61/73 64/93 84 69 68 84 2.68 0.24
 <2.00 ng/ml 61/73 62/93 84 67 66 84 2.51 0.25
 <3.00 ng/ml 63/73 54/93 86 58 62 84 2.06 0.24
 <4.00 ng/ml 67/73 49/93 92 53 60 89 1.94 0.16
 <5.00 ng/ml 69/73 43/93 95 46 58 91 1.76 0.12
  1. BDG (1,3)-β-d-glucan, LR+ positive likelihood ratio, LR– negative likelihood ratio, NPV negative predictive value, PCT procalcitonin, PPV positive predictive value, TN true negatives, TP true positives