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Table 4 Association study with septic and nonseptic individuals among 646 major trauma patients

From: The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

Clinical characteristics

Number of patients or mean ± SD

Sepsis (n = 199)

Nonsepsis (n = 447)

X/t

P value

Age, years, mean ± SD

41.8 ± 11.8

40.8 ± 7.4

42.2 ± 11.6

−1.397

0.163

Age range, years

16–65

16–65

16–65

  

Males/females, n

523/123

159/40

364/83

0.210

0.665

ISS, mean ± SD

24.3 ± 6.7

26.4 ± 7.4

23.4 ± 6.1

5.007

0.000

  ≥ 16 to <25, n

421

103

318

22.789

0.000

  ≥ 25, n

225

96

129

Severely injured body regions, n

 Head

29

7

22

3.487

0.993

 Thorax

99

28

71

 Abdomen

119

37

82

 Extremities

91

28

63

 Multiple

308

99

209

Organ dysfunction, n

 None

261

81

180

1.328

0.725

 One, n

177

53

124

 Two, n

126

43

83

 Three or above, n

82

22

60

Source of infection, n (%)

 Respiratory tract

293

89

204

  

 Primary bloodstream

143

50

93

 Urinary tract

103

33

70

 Catheter-associated

40

10

30

 Wound

40

11

29

 Others

26

6

20

Pathogens, n (%)

 Negative cultures

337

82

255

23.841

0.001

 Gram-negative

147

52

95

 Gram-positive

101

40

61

 Fungi

31

8

23

 Multiple infections

30

17

13

rs11666254, n (%)

 GG

219

50

169

15.599

0.000

 GA

310

98

212

 AA

117

51

66

 GA + AA

427

149

278

9.883

0.002

 GG + GA

529

148

381

10.956

0.001

  1. ISS Injury Severity Score, X/t Chi-square value/t value