The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

Table 3 Clinical relevance of the three tag single-nucleotide polymorphisms of the FPR2/ALX gene in 275 trauma patients

SNP	Genotype	Number	Age (years)	Sex (M/F)	ISS	Sepsis, n (%)	MOD score
rs11666254	GG	92	42.0 ± 12.2	73/19	24.5 ± 5.9	21 (22.8)^a	4.6 ± 1.7
	GA	134	42.7 ± 11.7	113/21	24.8 ± 7.1	41 (30.6)^a	4.4 ± 1.9
	AA	49	41.5 ± 11.1	36/13	24.3 ± 5.7	22 (44.9)^a	4.7 ± 1.3
rs17695052	AA	226	41.9 ± 11.5	185/41	24.4 ± 6.4	67 (29.6)	4.6 ± 1.8
	AG	45	43.6 ± 13.3	33/12	25.5 ± 6.7	17 (37.8)	4.4 ± 1.7
	GG	0	0	0	0	0	0
rs17695064	CC	233	42.2 ± 11.8	187/46	24.6 ± 6.3	72 (30.9)	4.6 ± 1.8
	CT	38	42.0 ± 12.0	31/7	24.7 ± 7.6	12 (31.6)	4.3 ± 1.8
	TT	0	0	0	0	0	0

ISS Injury Severity Score, MOD Multiple organ dysfunction, SNP Single-nucleotide polymorphism
Age and ISS are given as the mean ± SD; MOD score is given as the mean ± SE.
^aGG vs GA vs AA, P = 0.025; P = 0.049, GG vs GA + AA for dominant effect (variant homozygotes + heterozygotes vs wild homozygotes) by analysis of covariance

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