The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

Table 2 Overall clinical characteristics of patients with major trauma

Clinical characteristics	Total	Cohort 1 (n = 275)	Cohort 2 (n = 371)	P value
Age, years, mean ± SD	41.8 ± 11.8	42.3 ± 11.8	41.4 ± 12.0	0.362
Age range, years	16–65	16–65	16–65
Males/females, n	523/123	222/53	301/70	0.919
ISS, mean ± SD	24.3 ± 6.7	24.6 ± 6.5	24.2 ± 6.8	0.437
≥ 16 to <25, n	421	174	247	0.383
≥ 25, n	225	101	124	0.383
Severely injured body regions, n
Head	29	14	15	0.996
Thorax	99	42	57
Abdomen	119	51	68
Extremities	91	35	56
Multiple	308	133	175
MOD score	4.4 ± 2.0	4.6 ± 1.8	4.4 ± 2.2	0.212
Organ dysfunction, n (%)
None	261	109	152	0.959
One, n	177	76	101
Two, n	126	56	70
Three or more, n	82	34	48
Sepsis, n	199	84	115	0.931
Source of infection, n
Respiratory tract	293	122	171
Primary bloodstream	143	60	83
Urinary tract	103	42	61
Catheter-associated	40	18	22
Wound	40	19	21
Other^a	26	14	12
Pathogens, n
Negative cultures	337	143	194	0.238
Gram-negative	147	62	85
Gram-positive	101	43	58
Fungi	31	9	22
Multiple infection	30	18	12

ISS Injury Severity Score, MOD Multiple organ dysfunction
^aOther included other sources of infection, such as soft tissue, bone, ascites, mucosa, cerebrospinal fluid, nonconfirmed sources

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