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Fig. 3 | Critical Care

Fig. 3

From: The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma

Fig. 3

rs11666254 polymorphism and the transcription activity of the FPR2/ALX promoter. Relative luciferase activity (RLA) was used in human embryonic kidney cells transfected with rs11666254G or rs11666254A constructs as described in the Methods section. Luciferase activity was normalized for transfection efficiency using the control plasmid pRL-cytomegalovirus. These results are expressed as fold increases in RLA of the FPR2/ALX promoter construct vector compared with pGL3-basic (mean ± SD). *P = 0.03 vs the wild-type construct. LPS Lipopolysaccharide

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Critical Care

ISSN: 1364-8535