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Table 2 Mechanical ventilation settings through the years

From: The future of mechanical ventilation: lessons from the present and the past

  Brochard et al. [45] Stewart et al. [46] Brower et al. [47] ARDS Network [35] Esteban et al. [62] Brower et al. [75] Meade et al. [76] Briel et al. [77] Villar et al. [63] Guerin et al. [73] Bellani et al. [64]
Type RCT RCT RCT RCT Observation RCT RCT Meta-analysis Observation RCT Observation
Year 1998 1998 1999 2000 2002 2004 2008 2010 2011 2013 2016
Number of patients 58 58 60 60 100 100 387 405 231 236 258 508 475 1163 1136 255 229a 2377
Vt/PBW (ml/kg) 7.1 10.3 7.0 10.7 10.2 7.3 6.2 11.8 8.7 6.1 6 6.8 6.8 6.3 6.3 7.2 6.1 7.6
RR (bpm)    22.1 15.6    29 16 20 29 29 26 25.2     27 20.8
Peak pressure (cmH2O)    24.2 32.1    32 39 34          27
Plateau pressure (cmH2O) 25.7 31.7 22.3 26.8 30.6 24.9 25 33 28 24 27 24.9 30.2 23 29 26 23 23
PEEP (cmH2O) 10.7 10.7 8.6 7.2 ~8.2 ~9.5 9.4 8.6 8 8.9 14.7 10.1 15.6 9 15 9.3 10 8.5
Mortality (%) 46.6b 37.9b 50c 47c 46c 50c 31c 39.8c 52c 24.9c 27.5c 32.3d 28.4d 36.6c 30.3c 42.7c 32,8d 35.3c
  1. PBW predicted body weight, PEEP positive end-expiratory pressure, RCT randomized controlled trial, RR respiratory rate, Vt tidal volume
  2. a Supine group only
  3. b Fourteen-day mortality
  4. c ICU/hospital mortality
  5. d Twenty-eight-day mortality