|
Appropriate empirical antimicrobial therapy, % (n)
|
80% (98)
|
77% (47)
|
84% (51)
|
0.45
|
|
Early escalation, % (n)
|
7% (9)
|
0% (0)
|
15% (9)
|
<0.01*
|
|
Appropriate antimicrobial therapy after culture results, % (n)
|
88% (107)
|
77% (47)
|
98% (60)
|
<0.01
|
|
Delay before antimicrobial therapy escalation (h)
|
48 (28–60)
|
50.5 (48–73)
|
27 (24–28)
|
<0.01#
|
|
Optimal empirical antimicrobial therapy, % (n)
|
51% (62)
|
46% (28)
|
56% (34)
|
0.33
|
|
Early adaptation, % (n)
|
22% (27)
|
2% (1)
|
43% (26)
|
<0.01*
|
|
escalation
|
7% (9)
|
0% (0)
|
15% (9)
| |
|
de-escalation
|
15% (18)
|
2% (1)
|
28% (17)
| |
|
Optimal antimicrobial therapy after culture results, % (n)
|
71% (87)
|
48% (29)
|
95% (58)
|
<0.01
|
|
Delay before antimicrobial therapy adaptation (h)
|
49 (31.5–65)
|
58 (48–72)
|
28 (24.5–47)
|
<0.01#
|
|
Time to apyrexia (h)
|
24 (24–72)
|
24 (24–48)
|
30 (24–72)
|
0.19#
|
|
Time to leukocytosis <10.000/mm3 (days)
|
6 (3–13)
|
5 (3–12)
|
6 (3–15)
|
0.37#
|
|
Time to mechanical weaning (days)
|
5 (3–9)
|
4.5 (3–9)
|
5 (4–8)
|
0.51#
|
|
Length of ICU stay (days)
|
10 (5–16)
|
11 (6–17)
|
10 (5–15)
|
0.48
|
|
Mortality, % (n)
|
15% (18)
|
16% (10)
|
13% (8)
|
0.80
|
