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Fig. 1 | Critical Care

Fig. 1

From: Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids

Fig. 1

Endothelial glycocalyx thickness (top) in post-capillary venules and plasma syndecan-1 after shock followed by resuscitation with normal saline (9 rats, 48 vessels), lactated Ringer’s solution (LR) (7 rats, 34 vessels), 5% albumin (12 rats, 57 vessels) or fresh frozen plasma (FFP) (8 rats, 38 vessels). The sham-procedure group (time control) was not subjected to hemorrhage or resuscitation (7 rats, 29 vessels). Thickness was taken as the distance between the edge of the dextran column and the surface of the endothelium. In all the groups, resuscitation led to shedding of glycocalyx (p < 0.05), but glycocalyx thickness after saline was significantly lower than in the sham, 5% albumin and FFP groups (p < 0.05). Similarly, syndecan-1 levels were significantly higher with crystalloid resuscitation compared to colloids. Data for EG thickness are expressed as mean ± SD. Box plots for syndecan display median, interquartile ranges, minimum and maximum. aSignificantly different from the sham group. bSignificantly different from the 5% albumin group. cSignificantly different from the FFP group

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