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Table 1 Advantages and drawbacks of measurements performed by transpulmonary thermodilution and calibrated pulse contour analysis

From: Transpulmonary thermodilution: advantages and limits

Variable Main advantages Main drawbacks
Cardiac output measured by TPTD As reliable as pulmonary thermodilution Does not provide a continuous measurement
Cardiac output measured by pulse contour analysis Continuous measurement
Precise measurement
Assesses short-term and small changes
Requires regular recalibration
Global end-diastolic volume Better reflects cardiac preload than pressure markers of preload Does not distinguish between the right and left ventricles
Less directly reflects the risk of pulmonary oedema than PAOP
Stroke volume variation Continuous automated assessment of fluid responsiveness Cannot be used in case of spontaneous breathing, cardiac arrhythmias and ARDS
Cardiac function index, global ejection fraction Can be used as an alarm for decreased LV systolic function Overestimate LV systolic function in case of right ventricular dilation
Indirect markers of cardiac systolic function
Do not precisely assess cardiac structure and function
Extravascular lung water Directly estimates the volume of lung oedema Unreliable in case of pulmonary embolism, lung resection, large pleural effusions
Pulmonary vascular permeability index Directly estimates lung permeability
Distinguishes hydrostatic from permeability pulmonary oedema
Same as for extravascular lung water
  1. ARDS acute respiratory distress syndrome, LV left ventricular, PAOP pulmonary artery occlusion pressure, TPTD transpulmonary thermodilution