A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial

Table 7 Infection outcomes

Variable	EN only (n = 73)	SPN + EN (OLIMEL) (n = 52)	p value
Number of patients with a suspected infection	33/73 (45.2%)	26/52 (50.0%)	0.72
Total number of suspected infections	83	78
Average suspected infections per patient, ± SD	1.7 ± 2.6	1.9 ± 2.6	0.62
Number of patients with newly acquired infection	23/73 (31.5%)	14/52 (26.9%)	0.69
Total number of newly acquired infections	46	38
Adjudication^a
Definite	30 (65.2%)	18 (47.4%)
Possible	1 (2.2%)	2 (5.3%)
Probable	15 (32.6%)	18 (47.4%)
Type of newly acquired infection^a
Surgical deep	0 (0.0%)	1 (2.6%)
Skin/soft tissue	3 (6.5%)	0 (0.0%)
Catheter BSI	0 (0.0%)	7 (18.4%)
Primary BSI	1 (2.2%)	0 (0.0%)
Lower UTI	2 (4.3%)	5 (13.2%)
Upper UTI	0 (0.0%)	1 (2.6%)
Intra-abdominal	0 (0.0%)	4 (10.5%)
Lower RTI	17 (37.0%)	5 (13.2%)
ICU pneumonia	18 (39.1%)	12 (31.6%)
Other	5 (10.9%)	3 (7.9%)
Organism types^b	27	19
Bacteria	24 (88.9%)	14 (73.7%)
Fungi/yeast	2 (7.4%)	5 (26.3%)
Virus	1 (3.7%)	0 (0.0%)

Mean ± SD reported for continuous variables. Count (%) reported for categorical variables. Number of suspected and newly acquired infections was compared using the Fisher’s exact test, and the average number of infections per patient was compared using the Mann-Whitney U test
Abbreviations: BSI bloodstream infection, EN enteral nutrition, ICU intensive care unit, RTI respiratory tract infection, SD standard deviation, SPN supplemental parenteral nutrition, UTI urinary tract infection
^aThe denominator is the total number of newly acquired infections
^bThe denominator is the total number of newly acquired infections with organisms detected

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