A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial

Table 6 Clinical outcomes

Variable	EN only (n = 73)	SPN + EN (OLIMEL) (n = 52)	p value
Length of ventilation, days	8.3 (3.8–13.3)	6.5 (3.9–14.1)	0.78
ICU mortality			0.51
Yes	13 (17.8%)	7 (13.5%)
No, patient discharged	60 (82.2%)	45 (86.5%)
Length of stay in ICU among survivors, days	12.6 (8.1–18.7)	12.8 (7.9–17.8)	0.80
Hospital mortality			0.29
Yes	17 (23.3%)	8 (15.4%)
No, patient discharged	56 (76.7%)	43 (82.7%)
No, patient still in hospital at 6 months	0 (0.0%)	1 (1.9%)
Length of stay in hospital among survivors, days	24.0 (16.6–38.9)	23.5 (17.5–34.7)	0.83
Time to discharge alive from hospital	33.0 (20.2, und)	32.5 (21.1, und)	0.87
Kaplan-Meier 6-month mortality estimate^a	27.5%	29.5%	0.86

Data reported as median (Q1–Q3) or n (%). The Mann-Whitney U test was used for continuous variables, and the chi-square test was used for categorical variables. Survival analysis was used for comparison of time to discharge alive from hospital
Abbreviations: EN enteral nutrition, ICU intensive care unit, SPN supplemental parenteral nutrition, und undefined due to <75% reaching upper quartile
^aThe Kaplan-Meier estimate censors patients at the last known date alive. Altogether, 19 deaths were observed in the EN-alone arm, compared with 14 deaths in the SPN + EN arm. The median follow-up time among patients where death was not observed was 175 days in the EN-alone arm and 167 days in the SPN + PN arm

ISSN: 1364-8535