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Table 2 Characteristics of the pulmonary involvement (n = 102)

From: Severe varicella-zoster virus pneumonia: a multicenter cohort study

Variables  
Pulmonary symptoms (n = 102)
 Temperature, °C 39.2 (38.7–39.9)
 Dyspnea 96 (94%)
 Cough 45 (44%)
 Hemoptysis 9 (9%)
 Chest pain 10 (10%)
 Acute respiratory failure at ICU admission 69 (68%)
Chest X-ray at ICU admission (n = 97, 95%)
 Normal 1 (1%)
 Unilateral alveolar opacities 7 (8%)
 Bilateral alveolar opacities 23 (24%)
 Unilateral interstitial pattern 1 (1%)
 Bilateral interstitial pattern 68 (75%)
Lung CT scan (n = 31, 30%)
 Normal 0 (0%)
 Ground glass opacities 11 (39%)
 Nodules 14 (50%)
 Consolidations 14 (50%)
 Interlobular septal thickening 2 (8%)
 Pleural effusion 8 (29%)
Fiberoptic bronchoscopy (n = 35, 35%)a
 Inflammatory mucosa 6 (43%)
 Vesicular lesions on bronchial mucosa 6 (43%)
 Normal 2 (14%)
Bronchoalveolar lavage (n = 29, 28%)
 Diffuse intra-alveolar hemorrhageb 5 (29%)
 Cell count/μL (n = 11, 38%) 300,000 (215,000–675,000)
 Macrophages, % of total cells 50 (22–65)
 Lymphocytes, % of total cells 7.5 (5–20)
 Neutrophils, % of total cells 31 (5–63)
 Eosinophils, % of total cells 0 (0–2)
 Siderophages, % of total cells 0 (0–5)
 Virus identified by PCR in the BAL (24 samples) 23 (96%)
  1. Values are shown as n (%) or median (25th–75th percentiles)
  2. aFiberoptic bronchoscopy macroscopic findings were not available for 21 patients
  3. bMacroscopic examination of the fluid was not reported in 12 cases
  4. BAL bronchoalveolar lavage, CT computed tomography, ICU intensive care unit, PCR polymerase chain reaction