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Table 3 Diarrhea-associated events

From: A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient—the SPIRIT trial

 

Peptamen® AF (n = 46)

Isosource® Energy (n = 44)

Treatment effect

p value

 

n

n (%) with event

n

n (%) with event

Risk ratio (95% CI)

 

Patients that experienced diarrhea during their ICU stay

45

29 (64%)

44

31 (70%)

0.91 (0.68–1.22)

0.65

Patients receiving a fecal collector during their ICU stay

45

23 (51%)

44

24 (55%)

0.94 (0.63–1.39)

0.83

 

n

No. of events (pd)

n

No. of events (pd)

Rate ratio (95% CI)

 

Days with interruption of EN due to diarrhea

46

0 (253 pd)

44

2 (287 pd)

nd

0.28

 

n

Median (IQR)

n

Median (IQR)

Median difference a (95% CI)

 

Total costs of diarrhea per patient/day, CHF

45

3.66 (0.00–8.73)

44

2.60 (0.00–6.39)

0.00

(−0.36 to 2.70)

0.35

Nurse workload per patient/day, min

45

17.0 (0.0–38.5)

44

13.1 (0.0–21.5)

2.5 (−0.7 to 11.8)

0.28

  1. a Hodges–Lehman median differences
  2. CI confidence interval, EN enteral nutrition, ICU intensive care unit, IQR interquartile range, nd not defined, pd person days