Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

Table 4 Multivariable analysis with multiple imputation of clinical variables, S100, and neuron-specific enolase

			95% CI
Model S100 + NSE + clinical analysis	Effect	Odds ratio	Lower	Upper	p Value
Intercept	−6.480		0.00	0.01	<0.001
S100 at 24 h	1.012	2.751	0.49	15.33	0.25
S100 at 48 h	−1.808	0.164	0.00	6.89	0.34
S100 at 72 h	2.284	9.820	0.24	401.61	0.23
NSE at 24 h	−0.041	0.960	0.93	0.98	<0.001
NSE at 48 h	0.065	1.068	1.04	1.10	<0.001
NSE at 72 h	0.026	1.026	1.00	1.05	0.02
Target temperature	0.187	1.206	0.76	1.91	0.43
Age	0.091	1.095	1.07	1.12	<0.001
Time CA to ROSC	0.009	1.010	1.00	1.02	0.17
Lactate level on admission	0.003	1.003	0.94	1.07	0.93
Sex	−0.400	0.671	0.38	1.20	0.18
Bystander CPR performed	−0.706	0.494	0.29	0.83	0.01
VT/VF versus PEA/asystole	−1.062	0.346	0.17	0.72	<0.001
ROSC after bystander defibrillation	−0.926	0.396	0.07	2.11	0.28
Shock on admission	0.356	1.428	0.68	2.99	0.34

Abbreviations: CA Cardiac arrest, CPR Cardiopulmonary resuscitation, NSE Neuron-specific enolase, PEA Pulseless electrical activity, ROSC Return of spontaneous circulation, VF Ventricular fibrillation, VT Ventricular tachycardia

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