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Table 4 Multivariable analysis with multiple imputation of clinical variables, S100, and neuron-specific enolase

From: Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

    95% CI  
Model S100 + NSE + clinical analysis Effect Odds ratio Lower Upper p Value
Intercept −6.480   0.00 0.01 <0.001
S100 at 24 h 1.012 2.751 0.49 15.33 0.25
S100 at 48 h −1.808 0.164 0.00 6.89 0.34
S100 at 72 h 2.284 9.820 0.24 401.61 0.23
NSE at 24 h −0.041 0.960 0.93 0.98 <0.001
NSE at 48 h 0.065 1.068 1.04 1.10 <0.001
NSE at 72 h 0.026 1.026 1.00 1.05 0.02
Target temperature 0.187 1.206 0.76 1.91 0.43
Age 0.091 1.095 1.07 1.12 <0.001
Time CA to ROSC 0.009 1.010 1.00 1.02 0.17
Lactate level on admission 0.003 1.003 0.94 1.07 0.93
Sex −0.400 0.671 0.38 1.20 0.18
Bystander CPR performed −0.706 0.494 0.29 0.83 0.01
VT/VF versus PEA/asystole −1.062 0.346 0.17 0.72 <0.001
ROSC after bystander defibrillation −0.926 0.396 0.07 2.11 0.28
Shock on admission 0.356 1.428 0.68 2.99 0.34
  1. Abbreviations: CA Cardiac arrest, CPR Cardiopulmonary resuscitation, NSE Neuron-specific enolase, PEA Pulseless electrical activity, ROSC Return of spontaneous circulation, VF Ventricular fibrillation, VT Ventricular tachycardia