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Table 2 S100 cutoff values

From: Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

Time point   Cutoff (μg/L) Sensitivity 95% CI Specificity 95% CI
  S100 Youden 0.12 0.68 0.63–0.73 0.77 0.73–0.82
S100_5 0.25 0.41 0.35–0.46 0.95 0.93–0.97
S100_4 0.28 0.40 0.34–0.45 0.96 0.94–0.98
24 h S100_3 0.32 0.35 0.30–0.40 0.97 0.95–0.99
  S100_2 0.36 0.32 0.26–0.37 0.98 0.96–0.99
S100_1 0.72 0.22 0.17–0.26 0.99 0.97–1.00
S100_0 2.59 0.10 0.07–0.13 1.00 0.99–1.00
S100 Youden 0.13 0.63 0.57–0.68 0.82 0.78–0.86
S100_5 0.25 0.36 0.30–0.41 0.95 0.93–0.98
S100_4 0.25 0.36 0.30–0.41 0.96 0.94–0.98
48 h S100_3 0.27 0.34 0.28–0.39 0.97 0.95–0.99
  S100_2 0.28 0.34 0.28–0.39 0.98 0.96–0.99
S100_1 0.36 0.28 0.23–0.34 0.99 0.97–0.99
S100_0 3.67 0.05 0.03–0.08 1.00 0.99–1.00
S100 Youden 0.10 0.65 0.59–0.71 0.80 0.75–0.84
S100_5 0.19 0.35 0.29–0.40 0.95 0.92–0.97
S100_4 0.23 0.29 0.24–0.35 0.96 0.94–0.98
72 h S100_3 0.26 0.25 0.20–0.30 0.97 0.95–0.99
  S100_2 0.35 0.20 0.15–0.24 0.98 0.96–0.99
S100_1 0.52 0.15 0.11–0.19 0.99 0.97–0.99
S100_0 1.83 0.05 0.02–0.08 1.00 0.98–1.00
  1. S100 cutoff values for poor outcome prediction, pooled data for target temperature
  2. S100 Youden indicates S100 cutoff with the compromise of the best sensitivity and specificity (maximized Youden index). The number following S100 refers to the false-positive rate. Sensitivity and specificity are corrected by bootstrap internal validation