Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C

Table 2 S100 cutoff values

Time point		Cutoff (μg/L)	Sensitivity	95% CI	Specificity	95% CI
	S100 Youden	0.12	0.68	0.63–0.73	0.77	0.73–0.82
	S100_5	0.25	0.41	0.35–0.46	0.95	0.93–0.97
	S100_4	0.28	0.40	0.34–0.45	0.96	0.94–0.98
24 h	S100_3	0.32	0.35	0.30–0.40	0.97	0.95–0.99
	S100_2	0.36	0.32	0.26–0.37	0.98	0.96–0.99
	S100_1	0.72	0.22	0.17–0.26	0.99	0.97–1.00
	S100_0	2.59	0.10	0.07–0.13	1.00	0.99–1.00
	S100 Youden	0.13	0.63	0.57–0.68	0.82	0.78–0.86
	S100_5	0.25	0.36	0.30–0.41	0.95	0.93–0.98
	S100_4	0.25	0.36	0.30–0.41	0.96	0.94–0.98
48 h	S100_3	0.27	0.34	0.28–0.39	0.97	0.95–0.99
	S100_2	0.28	0.34	0.28–0.39	0.98	0.96–0.99
	S100_1	0.36	0.28	0.23–0.34	0.99	0.97–0.99
	S100_0	3.67	0.05	0.03–0.08	1.00	0.99–1.00
	S100 Youden	0.10	0.65	0.59–0.71	0.80	0.75–0.84
	S100_5	0.19	0.35	0.29–0.40	0.95	0.92–0.97
	S100_4	0.23	0.29	0.24–0.35	0.96	0.94–0.98
72 h	S100_3	0.26	0.25	0.20–0.30	0.97	0.95–0.99
	S100_2	0.35	0.20	0.15–0.24	0.98	0.96–0.99
	S100_1	0.52	0.15	0.11–0.19	0.99	0.97–0.99
	S100_0	1.83	0.05	0.02–0.08	1.00	0.98–1.00

S100 cutoff values for poor outcome prediction, pooled data for target temperature
S100 Youden indicates S100 cutoff with the compromise of the best sensitivity and specificity (maximized Youden index). The number following S100 refers to the false-positive rate. Sensitivity and specificity are corrected by bootstrap internal validation

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