Hours | Cohort 1: (n = 145 patients) | ||||
Survivors (%∆SI S ) % | Non-survivors (%∆SI NS ) % | Kolmogorov-Smirnov test p value | Median %∆SI S -%∆SI NS [95% CI] % | ||
Day 1 | |||||
 0–5 | 1.46 [−29.26, 54.74] | 11.67 [−20.84, 56.41] | 0.67 | −8.12 [−16.22, 4.67] | ⇔ |
 6–11 | 7.37 [−14.66, 42.05] | 9.47 [−11.45, 27.98] | 0.53 | −1.31 [−6.22, 5.74] | ⇔ |
 12–17 | 5.21 [−11.87, 30.89] | 6.69 [−14.89, 42.15] | 0.62 | −0.98 [−9.46, 7.26] | ⇔ |
 18–23 | 3.24 [−16.02, 26.92] | −0.63 [−12.21, 16.37] | 0.12 | 3.72 [−1.99, 8.56] | ⇔ |
Day 2 | |||||
 24–29 | 2.79 [−13.36, 23.35] | 5.37 [−9.42, 23.52] | 0.30 | −2.70 [−8.60, 3.29] | ⇔ |
 30–35 | 1.76 [−15.13, 23.46] | 1.57 [−11.32, 24.75] | 0.78 | 0.34 [−8.54, 6.75] | ⇔ |
 36–41 | 1.92 [−12.19, 16.87] | −4.01 [−15.63, 11.26] | 0.04 | 6.10 [0.35, 10.70] a | ⇔ |
 42–47 | −0.10 [−12.71, 17.98] | 5.46 [−10.91, 21.91] | 0.14 | −5.66 [−11.61, −0.43] a | ⇔ |
Day 3 | |||||
 48–53 | 1.57 [−10.74, 16.82] | 3.41 [−7.30, 14.99] | 0.30 | −2.12 [−7.41, 1.77] | ⇔ |
 54–59 | 0.67 [−11.68, 15.80] | −3.13 [−19.08, 11.65] | 0.35 | 3.37 [−1.77, 8.20] | ⇔ |
 60–65 | 2.39 [−12.39, 17.03] | 4.89 [−8.88, 21.88] | 0.45 | −2.50 [−9.06, 3.35] | ⇔ |
 66–71 | 1.26 [−9.80, 12.87] | 3.78 [−8.82, 15.48] | 0.35 | −2.76 [−8.66, 2.80] | ⇔ |
Hours | Cohort 2: (n = 80 patients) | ||||
Survivors (%∆SI S ) % | Non-survivors (%∆SI NS ) % | Kolmogorov-Smirnov test p value | Median %∆SI S -%∆SI NS [95% CI] % | ||
Day 1 | |||||
 0–5 | 0 [−29.44, 43.57] | 0.98 [−20.90, 57.81] | 0.78 | −0.98 [−16.02, 5.93] | ⇔ |
 6–11 | 8.80 [−14.66, 48.55] | 10.59 [−17.24, 39.20] | 0.90 | −2.17 [−11.46, 6.83] | ⇔ |
 12–17 | 2.38 [−13.18, 29.19] | 2.92 [−15.99, 38.92] | 0.89 | −0.02 [−11.00, 9.19] | ⇔ |
 18–23 | 4.09 [−14.80, 26.14] | −2.13 [−11.66, 15.29] | 0.11 | 6.16 [0.10, 12.10] a | ⇔ |
Day 2 | |||||
 24–29 | 1.32 [−13.48, 20.79] | 10.39 [−8.97, 25.86] | 0.02 | −9.23 [−14.18, −1.38] a | ⇔ |
 30–35 | 0.13 [−15.56, 21.72] | 3.08 [−13.33, 23.03] | 0.89 | −2.38 [−10.72, 4.79] | ⇔ |
 36–41 | 2.54 [−12.13, 18.20] | 0.40 [−11.95, 15.13] | 0.39 | 2.95 [−1.86, 9.51] | ⇔ |
 42–47 | 1.37 [−13.37, 22.76] | 2.42 [−11.83, 14.68] | 0.46 | −1.02 [−7.15, 5.68] | ⇔ |
Day 3 | |||||
 48–53 | 0.88 [−10.32, 16.63] | 3.16 [−7.25, 14.62] | 0.30 | −2.37 [−7.73, 1.79] | ⇔ |
 54–59 | 0.72 [−10.36, 14.28] | −1.17 [−19.08, 12.68] | 0.32 | 2.69 [−3.18, 7.71] | ⇔ |
 60–65 | 2.58 [−10.54, 16.38] | 4.04 [−9.03, 21.96] | 0.39 | −1.89 [−8.44, 3.76] | ⇔ |
 66–71 | 1.26 [−9.74, 11.54] | 3.72 [−9.06, 14.81] | 0.40 | −2.62 [−8.81, 3.12] | ⇔ |