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Table 5 Hour-to-hour percentage change in insulin sensitivity (%ΔSI) median [IQR] comparison between survivors and non-survivors using 6-h blocks

From: Untangling glycaemia and mortality in critical care

Hours Cohort 1: (n = 145 patients)
Survivors (%∆SI S ) % Non-survivors (%∆SI NS ) % Kolmogorov-Smirnov test p value Median %∆SI S -%∆SI NS [95% CI] %
Day 1
 0–5 1.46 [−29.26, 54.74] 11.67 [−20.84, 56.41] 0.67 −8.12 [−16.22, 4.67]
 6–11 7.37 [−14.66, 42.05] 9.47 [−11.45, 27.98] 0.53 −1.31 [−6.22, 5.74]
 12–17 5.21 [−11.87, 30.89] 6.69 [−14.89, 42.15] 0.62 −0.98 [−9.46, 7.26]
 18–23 3.24 [−16.02, 26.92] −0.63 [−12.21, 16.37] 0.12 3.72 [−1.99, 8.56]
Day 2
 24–29 2.79 [−13.36, 23.35] 5.37 [−9.42, 23.52] 0.30 −2.70 [−8.60, 3.29]
 30–35 1.76 [−15.13, 23.46] 1.57 [−11.32, 24.75] 0.78 0.34 [−8.54, 6.75]
 36–41 1.92 [−12.19, 16.87] −4.01 [−15.63, 11.26] 0.04 6.10 [0.35, 10.70] a
 42–47 −0.10 [−12.71, 17.98] 5.46 [−10.91, 21.91] 0.14 −5.66 [−11.61, −0.43] a
Day 3
 48–53 1.57 [−10.74, 16.82] 3.41 [−7.30, 14.99] 0.30 −2.12 [−7.41, 1.77]
 54–59 0.67 [−11.68, 15.80] −3.13 [−19.08, 11.65] 0.35 3.37 [−1.77, 8.20]
 60–65 2.39 [−12.39, 17.03] 4.89 [−8.88, 21.88] 0.45 −2.50 [−9.06, 3.35]
 66–71 1.26 [−9.80, 12.87] 3.78 [−8.82, 15.48] 0.35 −2.76 [−8.66, 2.80]
Hours Cohort 2: (n = 80 patients)
Survivors (%∆SI S ) % Non-survivors (%∆SI NS ) % Kolmogorov-Smirnov test p value Median %∆SI S -%∆SI NS [95% CI] %
Day 1
 0–5 0 [−29.44, 43.57] 0.98 [−20.90, 57.81] 0.78 −0.98 [−16.02, 5.93]
 6–11 8.80 [−14.66, 48.55] 10.59 [−17.24, 39.20] 0.90 −2.17 [−11.46, 6.83]
 12–17 2.38 [−13.18, 29.19] 2.92 [−15.99, 38.92] 0.89 −0.02 [−11.00, 9.19]
 18–23 4.09 [−14.80, 26.14] −2.13 [−11.66, 15.29] 0.11 6.16 [0.10, 12.10] a
Day 2
 24–29 1.32 [−13.48, 20.79] 10.39 [−8.97, 25.86] 0.02 −9.23 [−14.18, −1.38] a
 30–35 0.13 [−15.56, 21.72] 3.08 [−13.33, 23.03] 0.89 −2.38 [−10.72, 4.79]
 36–41 2.54 [−12.13, 18.20] 0.40 [−11.95, 15.13] 0.39 2.95 [−1.86, 9.51]
 42–47 1.37 [−13.37, 22.76] 2.42 [−11.83, 14.68] 0.46 −1.02 [−7.15, 5.68]
Day 3
 48–53 0.88 [−10.32, 16.63] 3.16 [−7.25, 14.62] 0.30 −2.37 [−7.73, 1.79]
 54–59 0.72 [−10.36, 14.28] −1.17 [−19.08, 12.68] 0.32 2.69 [−3.18, 7.71]
 60–65 2.58 [−10.54, 16.38] 4.04 [−9.03, 21.96] 0.39 −1.89 [−8.44, 3.76]
 66–71 1.26 [−9.74, 11.54] 3.72 [−9.06, 14.81] 0.40 −2.62 [−8.81, 3.12]
  1. Equivalence is indicated by , Non-equivalence is indicated by ×
  2. aHours where the medians are statistically different (95% CI on difference in medians does not cross zero)
  3. Bootstrapped confidence interval (CI) in bold is statistically significant to p<0.05