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Table 5 Hour-to-hour percentage change in insulin sensitivity (%ΔSI) median [IQR] comparison between survivors and non-survivors using 6-h blocks

From: Untangling glycaemia and mortality in critical care

Hours

Cohort 1: (n = 145 patients)

Survivors (%∆SI S ) %

Non-survivors (%∆SI NS ) %

Kolmogorov-Smirnov test p value

Median %∆SI S -%∆SI NS [95% CI] %

Day 1

 0–5

1.46 [−29.26, 54.74]

11.67 [−20.84, 56.41]

0.67

−8.12 [−16.22, 4.67]

⇔

 6–11

7.37 [−14.66, 42.05]

9.47 [−11.45, 27.98]

0.53

−1.31 [−6.22, 5.74]

⇔

 12–17

5.21 [−11.87, 30.89]

6.69 [−14.89, 42.15]

0.62

−0.98 [−9.46, 7.26]

⇔

 18–23

3.24 [−16.02, 26.92]

−0.63 [−12.21, 16.37]

0.12

3.72 [−1.99, 8.56]

⇔

Day 2

 24–29

2.79 [−13.36, 23.35]

5.37 [−9.42, 23.52]

0.30

−2.70 [−8.60, 3.29]

⇔

 30–35

1.76 [−15.13, 23.46]

1.57 [−11.32, 24.75]

0.78

0.34 [−8.54, 6.75]

⇔

 36–41

1.92 [−12.19, 16.87]

−4.01 [−15.63, 11.26]

0.04

6.10 [0.35, 10.70] a

⇔

 42–47

−0.10 [−12.71, 17.98]

5.46 [−10.91, 21.91]

0.14

−5.66 [−11.61, −0.43] a

⇔

Day 3

 48–53

1.57 [−10.74, 16.82]

3.41 [−7.30, 14.99]

0.30

−2.12 [−7.41, 1.77]

⇔

 54–59

0.67 [−11.68, 15.80]

−3.13 [−19.08, 11.65]

0.35

3.37 [−1.77, 8.20]

⇔

 60–65

2.39 [−12.39, 17.03]

4.89 [−8.88, 21.88]

0.45

−2.50 [−9.06, 3.35]

⇔

 66–71

1.26 [−9.80, 12.87]

3.78 [−8.82, 15.48]

0.35

−2.76 [−8.66, 2.80]

⇔

Hours

Cohort 2: (n = 80 patients)

Survivors (%∆SI S ) %

Non-survivors (%∆SI NS ) %

Kolmogorov-Smirnov test p value

Median %∆SI S -%∆SI NS [95% CI] %

Day 1

 0–5

0 [−29.44, 43.57]

0.98 [−20.90, 57.81]

0.78

−0.98 [−16.02, 5.93]

⇔

 6–11

8.80 [−14.66, 48.55]

10.59 [−17.24, 39.20]

0.90

−2.17 [−11.46, 6.83]

⇔

 12–17

2.38 [−13.18, 29.19]

2.92 [−15.99, 38.92]

0.89

−0.02 [−11.00, 9.19]

⇔

 18–23

4.09 [−14.80, 26.14]

−2.13 [−11.66, 15.29]

0.11

6.16 [0.10, 12.10] a

⇔

Day 2

 24–29

1.32 [−13.48, 20.79]

10.39 [−8.97, 25.86]

0.02

−9.23 [−14.18, −1.38] a

⇔

 30–35

0.13 [−15.56, 21.72]

3.08 [−13.33, 23.03]

0.89

−2.38 [−10.72, 4.79]

⇔

 36–41

2.54 [−12.13, 18.20]

0.40 [−11.95, 15.13]

0.39

2.95 [−1.86, 9.51]

⇔

 42–47

1.37 [−13.37, 22.76]

2.42 [−11.83, 14.68]

0.46

−1.02 [−7.15, 5.68]

⇔

Day 3

 48–53

0.88 [−10.32, 16.63]

3.16 [−7.25, 14.62]

0.30

−2.37 [−7.73, 1.79]

⇔

 54–59

0.72 [−10.36, 14.28]

−1.17 [−19.08, 12.68]

0.32

2.69 [−3.18, 7.71]

⇔

 60–65

2.58 [−10.54, 16.38]

4.04 [−9.03, 21.96]

0.39

−1.89 [−8.44, 3.76]

⇔

 66–71

1.26 [−9.74, 11.54]

3.72 [−9.06, 14.81]

0.40

−2.62 [−8.81, 3.12]

⇔

  1. Equivalence is indicated by ⇔, Non-equivalence is indicated by ×
  2. aHours where the medians are statistically different (95% CI on difference in medians does not cross zero)
  3. Bootstrapped confidence interval (CI) in bold is statistically significant to p<0.05