Hours | Cohort 1: (n = 145 patients) | |||
Survivors (SI S ) L/mU/minute × 10−4 | Non-survivors (SI NS ) L/mU/minute × 10−4 | Median SI S   − SI NS [95% CI] L/mU/minute × 10−4 | ||
Day 1 | ||||
 0–5 | 1.39 [0.50, 2.54] | 1.64 [0.63, 2.63] | −0.25 [−0.60, 0.06] | × |
 6–11 | 1.94 [1.11, 3.35] | 2.58 [1.42, 3.97] | −0.63 [−1.04, −0.11] a,b | × |
 12–17 | 2.54 [1.42, 4.48] | 3.39 [1.63, 4.79] | −0.79 [−1.46, 0.22] | × |
 18–23 | 2.76 [1.57, 5.09] | 3.22 [1.93, 5.16] | −0.42 [−0.93, 0.14] | × |
Day 2 | ||||
 24–29 | 2.96 [1.65, 4.98] | 3.30 [1.81, 4.85] | −0.30 [−0.73, 0.13] | × |
 30–35 | 3.08 [1.83, 5.73] | 4.34 [2.35, 7.21] | −1.23 [−2.16, −0.20] a | × |
 36–41 | 3.13 [1.81, 5.44] | 3.42 [2.23, 5.36] | −0.29 [−1.01, 0.43] | × |
 42–47 | 3.22 [1.81, 5.47] | 4.43 [2.48, 6.24] | −0.25 [−0.94, 0.16] | × |
Day 3 | ||||
 48–53 | 3.28 [1.95, 5.36] | 4.83 [3.13, 8.63] | −1.57 [−2.36, −0.97] a,b | × |
 54–59 | 3.55 [2.03, 5.50] | 4.65 [2.53, 7.27] | −1.12 [−2.04, −0.40] a | × |
 60–65 | 3.39 [2.18, 5.18] | 4.19 [2.71, 6.83] | −0.81 [−1.59, −0.01] a | × |
 66–71 | 3.40 [2.43, 5.07] | 3.86 [2.43, 8.30] | −0.47 [−1.43, 0.16] | × |
Hours | Cohort 2: (n = 80 patients) | |||
Survivors (SI S ) L/mU/minute × 10−4 | Non − Survivors (SI NS ) L/mU/minute × 10−4 | Median SI S   − SI NS [95% CI] L/mU/minute × 10−4 | ||
Day 1 | ||||
 0–5 | 1.39 [0.43, 2.45] | 1.38 [0.30, 2.54] | −0.00 [−0.52, 0.57] | × |
 6–11 | 1.90 [0.92, 3.66] | 2.22 [1.15, 3.62] | −0.33 [−1.00, 0.02] | × |
 12–17 | 2.36 [1.37, 4.48] | 2.46 [1.46, 4.50] | −0.12 [−1.19, 0.61] | × |
 18–23 | 2.63 [1.53, 4.47] | 2.94 [1.87, 4.50] | −0.30 [−0.81, 0.14] | × |
Day 2 | ||||
 24–29 | 2.95 [1.53, 4.52] | 3.19 [1.65, 4.82] | −0.26 [−0.75, 0.22] | × |
 30–35 | 3.04 [1.88, 5.07] | 3.56 [2.24, 6.85] | −0.55 [−1.95, 0.12] | × |
 36–41 | 3.06 [1.79, 4.94] | 3.15 [2.14, 5.04] | −0.10 [−0.79, 0.51] | × |
 42–47 | 3.21 [1.80, 5.23] | 3.41 [2.93, 5.27] | −0.24 [−0.86, 0.22] | × |
Day 3 | ||||
 48–53 | 3.31 [1.98, 5.30] | 4.59 [3.03, 8.20] | −1.26 [−1.84, −0.41] a,b | × |
 54–59 | 3.59 [2.09, 5.50] | 4.37 [2.43, 7.36] | −0.87 [−1.81, −0.09] a | × |
 60–65 | 3.45 [2.18, 5.24] | 3.94 [2.62, 6.53] | −0.48 [−1.37, 0.25] | × |
 66–71 | 3.41 [2.43, 5.21] | 3.68 [2.42, 7.56] | −0.30 [−1.20, 0.24] | × |