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Table 4 SI level (L/mU/minute) median [IQR] comparison between survivors and non-survivors using 6-h blocks

From: Untangling glycaemia and mortality in critical care

Hours

Cohort 1: (n = 145 patients)

Survivors (SI S ) L/mU/minute × 10−4

Non-survivors (SI NS ) L/mU/minute × 10−4

Median SI S   − SI NS [95% CI] L/mU/minute × 10−4

Day 1

 0–5

1.39 [0.50, 2.54]

1.64 [0.63, 2.63]

−0.25 [−0.60, 0.06]

×

 6–11

1.94 [1.11, 3.35]

2.58 [1.42, 3.97]

−0.63 [−1.04, −0.11] a,b

×

 12–17

2.54 [1.42, 4.48]

3.39 [1.63, 4.79]

−0.79 [−1.46, 0.22]

×

 18–23

2.76 [1.57, 5.09]

3.22 [1.93, 5.16]

−0.42 [−0.93, 0.14]

×

Day 2

 24–29

2.96 [1.65, 4.98]

3.30 [1.81, 4.85]

−0.30 [−0.73, 0.13]

×

 30–35

3.08 [1.83, 5.73]

4.34 [2.35, 7.21]

−1.23 [−2.16, −0.20] a

×

 36–41

3.13 [1.81, 5.44]

3.42 [2.23, 5.36]

−0.29 [−1.01, 0.43]

×

 42–47

3.22 [1.81, 5.47]

4.43 [2.48, 6.24]

−0.25 [−0.94, 0.16]

×

Day 3

 48–53

3.28 [1.95, 5.36]

4.83 [3.13, 8.63]

−1.57 [−2.36, −0.97] a,b

×

 54–59

3.55 [2.03, 5.50]

4.65 [2.53, 7.27]

−1.12 [−2.04, −0.40] a

×

 60–65

3.39 [2.18, 5.18]

4.19 [2.71, 6.83]

−0.81 [−1.59, −0.01] a

×

 66–71

3.40 [2.43, 5.07]

3.86 [2.43, 8.30]

−0.47 [−1.43, 0.16]

×

Hours

Cohort 2: (n = 80 patients)

Survivors (SI S ) L/mU/minute × 10−4

Non − Survivors (SI NS ) L/mU/minute × 10−4

Median SI S   − SI NS [95% CI] L/mU/minute × 10−4

Day 1

 0–5

1.39 [0.43, 2.45]

1.38 [0.30, 2.54]

−0.00 [−0.52, 0.57]

×

 6–11

1.90 [0.92, 3.66]

2.22 [1.15, 3.62]

−0.33 [−1.00, 0.02]

×

 12–17

2.36 [1.37, 4.48]

2.46 [1.46, 4.50]

−0.12 [−1.19, 0.61]

×

 18–23

2.63 [1.53, 4.47]

2.94 [1.87, 4.50]

−0.30 [−0.81, 0.14]

×

Day 2

 24–29

2.95 [1.53, 4.52]

3.19 [1.65, 4.82]

−0.26 [−0.75, 0.22]

×

 30–35

3.04 [1.88, 5.07]

3.56 [2.24, 6.85]

−0.55 [−1.95, 0.12]

×

 36–41

3.06 [1.79, 4.94]

3.15 [2.14, 5.04]

−0.10 [−0.79, 0.51]

×

 42–47

3.21 [1.80, 5.23]

3.41 [2.93, 5.27]

−0.24 [−0.86, 0.22]

×

Day 3

 48–53

3.31 [1.98, 5.30]

4.59 [3.03, 8.20]

−1.26 [−1.84, −0.41] a,b

×

 54–59

3.59 [2.09, 5.50]

4.37 [2.43, 7.36]

−0.87 [−1.81, −0.09] a

×

 60–65

3.45 [2.18, 5.24]

3.94 [2.62, 6.53]

−0.48 [−1.37, 0.25]

×

 66–71

3.41 [2.43, 5.21]

3.68 [2.42, 7.56]

−0.30 [−1.20, 0.24]

×

  1. Non-equivalence is indicated by ×, Equivalence is indicated by ⇔
  2. aHours where the medians are statistically different (95% CI on difference in medians does not cross zero)
  3. bDifferences remaining significant after Bonferroni correction (99.6% CI on difference in medians does not cross zero)
  4. Bootstrapped confidence interval (CI) in bold is statistically significant to p<0.05