Untangling glycaemia and mortality in critical care

Table 2 Baseline data from Cohort 2, comprising 80 patients treated according to Specialised Relative Insulin Nutrition Tables protocol

	Cohort 2	Survivors	Non-survivors	p Value
Number of subjects	80	63	17
Age, years	66 [54–75]	65 [49–74]	73 [57–76]	0.50
Sex, M/F	51/29	41/22	10/7	0.78
APACHE II score	21 [17–27]	21 [16–27]	21 [17–28]	0.60
First-day SOFA score	7 [4–8]	6 [4–8]	8 [6–8]	0.11
Cardiac	3 [1–4]	3 [1–4]	4 [2–4]
Pulmonary	3 [2–4]	3 [2–4]	4 [2–4]
Hepatic	0 [0–0]	0 [0–0]	0 [0–1]
Renal	0 [0–0]	0 [0–0]	0 [0–0]
Coagulation	0 [0–1]	0 [0–1]	0 [0–1]
ICU length of stay, h	180 [136–371]	214 [142–405]	142 [108–159]	<0.01
SPRINT duration, h	155 [109–301]	161 [126–332]	110 [102–151]	0.01
Diabetes mellitus type 1/type 2, % of total	5/10 (15)	4/8 (12)	1/2 (3)	1.00
Cohort BG, mmol/L	5.7 [5.0–6.7]	5.8 [5.1–6.8]	5.6 [4.9–6.5]	<0.01^a
Per-patient BG, mmol/L	5.8 [5.3–6.2]	5.9 [5.4–6.2]	5.4 [5.2–6.0]	0.11
Per-patient % BG, 4.4–8 mmol/L, % of all BG	84.7 [73.6–91.7] (81.3)	84.7 [74.0–91.7] (81.5)	83.3 [71.5–94.8] (80.7)	0.98
Per-patient % BG <4 mmol/L, % of all BG	1.4 [0.0–2.8] (2.5)	1.4 [0.0–2.8] (2.0)	1.4 [0.0–5.6] (4.2)	0.31
Number of patients with BG <2.2 mmol/L	0	0	0
BG measurements per day	15.1 [13.8–16.3]	15.1 [13.4–16.7]	15.4 [14.7–15.9]	0.66
Per-patient median insulin, U/h	3 [2–3]	3 [3–3]	3 [2–3]	0.40
Per-patient median feed, g/h	3.3 [1.9–4.8]	3.5 [1.9–4.6]	2.8 [2.1–5.6]	0.80

Data are given as median [IQR] unless otherwise indicated. p Values were computed using Fisher’s exact test and rank-sum tests where appropriate
Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, BG Blood glucose, ICU Intensive care unit, SOFA Sequential Organ Failure Assessment, SPRINT Specialised Relative Insulin Nutrition Tables protocol
^aEquivalence, as explained in ‘Analyses and statistics’ subsection under ‘Methods’

ISSN: 1364-8535