Table 1 Baseline data of Cohort 1, comprising 145 patients treated according to Specialised Relative Insulin Nutrition Tables protocol
| Â | Cohort 1 | Survivors | Non-survivors | p Value |
|---|---|---|---|---|
Number of subjects | 145 | 119 (82%) | 26 (18%) | Â |
Age, years | 67 [57–75] | 66 [57–74] | 73 [59–78] | 0.15 |
Sex, M/F | 91/54 | 75/44 | 16/10 | 1.00 |
APACHE II score | 20 [17–26] | 19 [16–25] | 22 [19–31] | <0.01 |
First-day SOFA score | 6 [4–8] | 6 [4–8] | 8 [6–8] | 0.02 |
 Cardiac | 3 [1–4] | 3 [1–4] | 4 [1–4] |  |
 Pulmonary | 3 [2–4] | 3 [2–3] | 3 [2–4] |  |
 Hepatic | 0 [0–0] | 0 [0–0] | 0 [0–1] |  |
 Renal | 0 [0–0] | 0 [0–0] | 0 [0–0] |  |
 Coagulation | 0 [0–1] | 0 [0–1] | 0 [0–0] |  |
ICU length of stay, h | 113 [65–212] | 127 [65–256] | 108 [65–154] | 0.49 |
SPRINT duration, h | 83 [44–159] | 81 [42–168] | 101.5 [55–126] | 0.93 |
Diabetes mellitus type 1/type 2, % of total | 9/24 (33) | 8/21 (29) | 1/3 (4) | 1.00 |
Cohort BG, mmol/L | 5.7 [4.9–6.7] | 5.8 [5.0–6.8] | 5.5 [4.8–6.4] | <0.01a |
Per-patient BG, mmol/L | 5.7 [5.2–6.2] | 5.8 [5.2–6.2] | 5.3 [5.1–5.9] | 0.03 |
Per-patient % BG 4.4–8 mmol/L (% all BG) | 82.8 [71.9–89.5] (79.3) | 82.1 [72.2–89.3] (79.1) | 83.3 [70.4–94.4] (80.0) | 0.71 |
Per-patient % BG <4 mmol/L (% all BG) | 1.4 [0.0–5.6] (3.4) | 1.4 [0.0–4.2] (3.0) | 1.9 [0.0–8.5] (5.0) | 0.19 |
Patients with BG <2.2 mmol/L, n | 0 | 0 | 0 | Â |
BG measurements per day | 15.8 [14.5–17.7] | 15.8 [14.4–18.0] | 15.7 [14.8–16.2] | 0.80 |
Per-patient median insulin, U/h | 3 [2–3] | 3 [2–3] | 3 [2–3] | 0.34 |
Per-patient median feed, g/h | 3.2 [1.9–4.8] | 3.3 [1.9–4.5] | 3.1 [2.0–5.3] | 0.58 |