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Table 3 Meta-analysis of outcomes of early versus late RRT in patients with AKI post cardiac surgery

From: Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis

Outcomes or subgroup analysis Studies Study reference number Patients OR/MD (95% CI) I 2 P
Primary outcomes: the effect of early versus late RRT on mortality
Mortality at 28 days 15 [17,18,19,20, 23,24,25,26,27,28,29,30,31,32,33] 1479 0.36 (0.23, 0.57)] 60% <0.01
Secondary outcomes: the relationship between early versus late RRT and mortality
ICU LOS 8 [18, 23,24,25,26,27, 29, 30] 745 MD -2.50 (-3.53, -1.47) 88% <0.01
Hospital LOS 8 [18, 20, 24,25,26,27, 29, 30] 887 MD -0.69 (-1.13, -0.25)] 88% 0.002
Duration of RRT 5 [20, 24, 26, 27, 30] 599 MD -1.18 (-2.26, -0.11) 69% 0.03
Subgroup analysis: the effect of the time of starting early RRT on mortality
RRT initiation within 12 h 6 [18, 19, 23, 30, 32, 33] 429 0.23 (0.08, 0.63) 73% 0.005
RRT initiation within 24 h 4 [17, 20, 24, 26] 562 0.52 (0.28, 0.95) 58% 0.03
RRT initiation within 48 h 3 [25, 28, 29] 265 0.43 (0.17, 1.09) 15% 0.08
Subgroup analysis: the relationship between RRT modality and mortality
CRRT 8 [18, 19, 23, 24, 26, 29, 30, 33] 668 0.36 (0.19, 0.67) 55% 0.001
IHD 5 [20, 25, 28, 31, 32] 384 0.27 (0.11, 0.66) 50% 0.004
CRRT/IHD 2 [17, 27] 427 0.53 (0.15, 1.86) 89% 0.32
Subgroup analysis: the relationship between study design and mortality
RCTs 5 [17, 18, 23, 25, 33] 426 0.41 (0.14, 1.24) 74% 0.11
Cohort studies 10 [19, 20, 24, 26,27,28,29,30,31,32] 1053 0.33 (0.23, 0.46) 15% <0.00001
Subgroup analysis: the relationship between AKI classification on the basis of 2012 KDIGO criteria and mortality
KDIGO 1 7 [18, 19, 23, 25, 27, 29, 30] 762 0.40 (0.23, 0.69) 46% 0.001
KDIGO 2 2 [32, 33] 99 0.04 (0.01, 0.15) 0% <0.00001
KDIGO 3 2 [24, 26] 125 0.31 (0.14, 0.66) 0% 0.003
Unclassified 4 [17, 20, 28, 31] 493 0.66 (0.41, 1.07) 23% 0.09
  1. Abbreviations: RRT renal replacement therapy, AKI acute kidney injury, RCT randomized controlled trials, OR odds ratio, CI confidence interval, ICU intensive care unit, CRRT continuous renal replacement therapy, IHD Intermittent hemodialysis, LOS length of stay, MD, mean difference, KDIGO Kidney Disease: Improving Global Outcomes