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Table 4 Impact of different cutoffs for the time-to-appropriate antibiotic (TtAa) on 28-day crude mortality in adults categorized by Pitt bacteremia score (PBS) on arrival at the emergency department

From: Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia

TtAa (hours) Mortality rate (%) Univariate analysis
≤ TtAa > TtAa OR (95% CI) P value
Mildly ill (PBS = 0, n = 633)
 1 3.6 8.4 0.41 (0.20–0.85) 0.01
 6 3.6 8.8 0.39 (0.19–0.80) 0.008
 12 3.8 8.3 0.43 (0.21–0.90) 0.02
 24 3.7 9.1 0.38 (0.18–0.80) 0.008
 48 3.6 10.2 0.33 (0.16–0.69) 0.002
 72 3.8 10.5 0.34 (0.16–0.73) 0.004
 96 4.4 8.5 0.48 (0.20–1.17) 0.10
Moderately ill (PSB = 1–3, n = 1240)
 1 6.0 11.6 0.48 (0.31–0.75) 0.001
 6 6.3 10.7 0.56 (0.36–0.88) 0.01
 12 6.3 11.1 0.54 (0.34–0.84) 0.006
 24 6.3 11.9 0.50 (0.32–0.80) 0.003
 48 6.3 13.0 0.45 (0.28–0.73) 0.001
 72 6.6 12.6 0.49 (0.29–0.81) 0.005
 96 6.8 13.1 0.48 (0.28–0.84) 0.009
Critical ill (PBS ≥4, n = 476)
 1 36.4 58.2 0.41 (0.28–0.60) <0.001
 6 40.1 57.8 0.49 (0.33–0.73) <0.001
 12 40.8 57.8 0.50 (0.34–0.75) 0.001
 24 41.7 58.7 0.50 (0.33–0.78) 0.002
 48 41.3 62.5 0.42 (0.27–0.67) <0.001
 72 41.1 62.4 0.43 (0.23–0.60) <0.001
 96 41.2 62.5 0.43 (0.24–0.62) <0.001
  1. OR odds ratio, CI confidence interval