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Table 3 Critical illness, fatal comorbidities, and 28-day mortality rates among adults with community-onset bacteremia

From: Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia

TtAa cutoffs (number of cases) Percentage (number of cases) 28-day Mortality rate (number of cases) Univariate analysis Cox regression
Critical illnessa Fatal comorbidity OR (95% CI) P value AOR (95% CI)b P value
1 hour
 ≤1 (n = 1663) 16.5 (275) 22.4 (373) 10.3 (172) 0.36 (0.28–0.45) <0.001 0.57 (0.46–0.71) <0.001
 >1 (n = 686) 29.3 (201) 27.8 (191) 24.5 (168)
6 hours
 ≤6 (n = 1736) 19.0 (329) 23.1 (401) 12.0 (208) 0.50 (0.39–0.63) <0.001 0.65 (0.51–0.82) <0.001
 >6 (n = 613) 24.0 (147) 26.6 (163) 21.5 (132)
12 hours
 ≤12 (n = 1760) 19.4 (341) 23.4 (412) 12.3 (216) 0.53 (0.41–0.67) <0.001 0.65 (0.52–0.83) <0.001
 >12 (n = 589) 22.9 (135) 25.8 (152) 21.1 (124)
24 hours
 ≤24 (n = 1,853) 19.8 (367) 23.5 (436) 12.6 (234) 0.53 (0.41–0.69) <0.001 0.62 (0.48–0.79) <0.001
 >24 (n = 496) 22.0 (109) 25.8 (128) 21.4 (106)
48 hours
 ≤48 (n = 1,917) 19.8 (380) 23.5 (450) 12.5 (240) 0.48 (0.37–0.62) <0.001 0.54 (0.43–0.71) <0.001
 >48 (n = 432) 22.2 (96) 26.4 (114) 23.1 (100)
72 hours
 ≤72 (n = 1,981) 19.5 (387) 23.4 (463) 12.6 (249) 0.44 (0.33–0.57) <0.001 0.55 (0.43–0.71) <0.001
 >72 (n = 368) 24.2 (89) 27.4 (101) 24.7 (91)
96 hours
 ≤96 (n = 2,061) 19.4 (400) 23.5 (484) 12.8 (264) 0.41 (0.31–0.55) <0.001 0.56 (0.44–0.72) <0.001
 >96 (n = 288) 26.4 (76) 27.8 (80) 26.4 (76)
  1. The significance of the effects of different cutoffs of the time to appropriate antibiotic (TtAa) on 28-day mortality were examined by univariate and Cox regression analyses. OR odds ratio, CI confidence interval, AOR adjusted odds ratio. aPitt bacteremia score ≥4 on arrival at the emergency department. bAdjusted for independent predictors of 28-day mortality recognized in the multivariate regression: critical illness; a fatal comorbidity (McCabe classification); polymicrobial bacteremia; Extended-spectrum beta-lactamase-producing bacteremia; bacteremia because of pneumonia or urinary tract infections; and underlying malignancy or liver cirrhosis