Variable | 28-day Mortality, number of cases (%) | P value | |
---|---|---|---|
Yes (n = 340) | No (n = 2009) | ||
Age ≥65 years | 223 (65.6) | 1,227 (61.1) | 0.11 |
Gender, male | 205 (60.3) | 1,004 (50.0) | <0.001 |
Nursing-home residents | 42 (12.4) | 91 (4.5) | <0.001 |
Severity-of-illness markers at arrival in the ED | |||
Pitt bacteremia score ≥4 | 217 (63.8) | 259 (12.9) | <0.001 |
Initial sepsis-related syndrome | |||
Severe sepsis | 289 (85.0) | 734 (36.5) | <0.001 |
Septic shock | 225 (66.2) | 254 (12.6) | <0.001 |
Ultimately and rapidly fatal comorbidity (McCabe classification) | 159 (46.8) | 405 (20.2) | <0.001 |
Polymicrobial bacteremia | 62 (18.2) | 178 (8.9) | <0.001 |
Major causative microorganisms | |||
Escherichia coli | 88 (25.9) | 880 (43.8) | <0.001 |
Klebsiella pneumoniae | 77 (22.6) | 277 (13.8) | <0.001 |
Staphylococcus aureus | 53 (15.6) | 259 (12.9) | 0.18 |
Streptococcus species | 45 (13.2) | 237 (11.8) | 0.45 |
Pseudomonas species | 28 (8.2) | 61 (3.0) | <0.001 |
ESBL-producing EKP | 27 (7.9) | 52 (2.6) | <0.001 |
Major bacteremia sources | |||
Pneumonia | 120 (35.3) | 205 (10.2) | <0.001 |
Urinary tract infection | 39 (11.5) | 709 (35.3) | <0.001 |
Biliary tract infection | 20 (5.9) | 200 (10.0) | 0.02 |
Intra-abdominal infection | 47 (13.8) | 265 (13.2) | 0.75 |
Liver abscess | 4 (1.2) | 75 (3.7) | 0.02 |
Skin and soft-tissue infection | 36 (10.6) | 208 (10.4) | 0.90 |
Primary bacteremia | 31 (9.1) | 150 (7.5) | 0.29 |
Major comorbidities | |||
Malignancy | 159 (46.8) | 500 (24.9) | <0.001 |
Hypertension | 140 (41.2) | 978 (48.7) | 0.01 |
Diabetes mellitus | 117 (34.4) | 758 (37.7) | 0.24 |
Chronic kidney disease | 58 (17.1) | 361 (18.0) | 0.69 |
Neurological disease | 95 (27.9) | 427 (21.3) | 0.006 |
Liver cirrhosis | 70 (20.6) | 231 (11.5) | <0.001 |
Laboratory data on arrival at the ED | |||
Leukocytes (103/mm3) | 14.8 ± 25.7 | 12.5 ± 7.2 | 0.11 |
Platelet (103/mm3) | 162.4 ± 123.1 | 199.4 ± 114.4 | <0.001 |
Serum creatinine (mg/dL) | 2.4 ± 3.0 | 2.2 ± 15.3 | 0.76 |
C-reactive protein (mg/L) | 162.3 ± 147.5 | 113.8 ± 118.9 | <0.001 |