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Table 1 Patient demography, bacteremia severity, comorbidity severity, causative microorganisms, and laboratory data for adults with community-onset bacteremia, categorized by 28-day crude mortality

From: Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia

Variable 28-day Mortality, number of cases (%) P value
Yes (n = 340) No (n = 2009)
Age ≥65 years 223 (65.6) 1,227 (61.1) 0.11
Gender, male 205 (60.3) 1,004 (50.0) <0.001
Nursing-home residents 42 (12.4) 91 (4.5) <0.001
Severity-of-illness markers at arrival in the ED
 Pitt bacteremia score ≥4 217 (63.8) 259 (12.9) <0.001
 Initial sepsis-related syndrome    
 Severe sepsis 289 (85.0) 734 (36.5) <0.001
 Septic shock 225 (66.2) 254 (12.6) <0.001
Ultimately and rapidly fatal comorbidity (McCabe classification) 159 (46.8) 405 (20.2) <0.001
Polymicrobial bacteremia 62 (18.2) 178 (8.9) <0.001
Major causative microorganisms
Escherichia coli 88 (25.9) 880 (43.8) <0.001
Klebsiella pneumoniae 77 (22.6) 277 (13.8) <0.001
Staphylococcus aureus 53 (15.6) 259 (12.9) 0.18
Streptococcus species 45 (13.2) 237 (11.8) 0.45
Pseudomonas species 28 (8.2) 61 (3.0) <0.001
 ESBL-producing EKP 27 (7.9) 52 (2.6) <0.001
Major bacteremia sources
 Pneumonia 120 (35.3) 205 (10.2) <0.001
 Urinary tract infection 39 (11.5) 709 (35.3) <0.001
 Biliary tract infection 20 (5.9) 200 (10.0) 0.02
 Intra-abdominal infection 47 (13.8) 265 (13.2) 0.75
 Liver abscess 4 (1.2) 75 (3.7) 0.02
 Skin and soft-tissue infection 36 (10.6) 208 (10.4) 0.90
 Primary bacteremia 31 (9.1) 150 (7.5) 0.29
Major comorbidities
 Malignancy 159 (46.8) 500 (24.9) <0.001
 Hypertension 140 (41.2) 978 (48.7) 0.01
 Diabetes mellitus 117 (34.4) 758 (37.7) 0.24
 Chronic kidney disease 58 (17.1) 361 (18.0) 0.69
 Neurological disease 95 (27.9) 427 (21.3) 0.006
 Liver cirrhosis 70 (20.6) 231 (11.5) <0.001
Laboratory data on arrival at the ED
 Leukocytes (103/mm3) 14.8 ± 25.7 12.5 ± 7.2 0.11
 Platelet (103/mm3) 162.4 ± 123.1 199.4 ± 114.4 <0.001
 Serum creatinine (mg/dL) 2.4 ± 3.0 2.2 ± 15.3 0.76
 C-reactive protein (mg/L) 162.3 ± 147.5 113.8 ± 118.9 <0.001
  1. ED emergency department, ESBL extended-spectrum beta-lactamase, EKP Escherichia coli, Klebsiella species, and Proteus mirabilis
  2. All variables are expressed as number of cases (%), but laboratory data as mean ± standard deviation