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Table 1 Patient demography, bacteremia severity, comorbidity severity, causative microorganisms, and laboratory data for adults with community-onset bacteremia, categorized by 28-day crude mortality

From: Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia

Variable

28-day Mortality, number of cases (%)

P value

Yes (n = 340)

No (n = 2009)

Age ≥65 years

223 (65.6)

1,227 (61.1)

0.11

Gender, male

205 (60.3)

1,004 (50.0)

<0.001

Nursing-home residents

42 (12.4)

91 (4.5)

<0.001

Severity-of-illness markers at arrival in the ED

 Pitt bacteremia score ≥4

217 (63.8)

259 (12.9)

<0.001

 Initial sepsis-related syndrome

   

 Severe sepsis

289 (85.0)

734 (36.5)

<0.001

 Septic shock

225 (66.2)

254 (12.6)

<0.001

Ultimately and rapidly fatal comorbidity (McCabe classification)

159 (46.8)

405 (20.2)

<0.001

Polymicrobial bacteremia

62 (18.2)

178 (8.9)

<0.001

Major causative microorganisms

Escherichia coli

88 (25.9)

880 (43.8)

<0.001

Klebsiella pneumoniae

77 (22.6)

277 (13.8)

<0.001

Staphylococcus aureus

53 (15.6)

259 (12.9)

0.18

Streptococcus species

45 (13.2)

237 (11.8)

0.45

Pseudomonas species

28 (8.2)

61 (3.0)

<0.001

 ESBL-producing EKP

27 (7.9)

52 (2.6)

<0.001

Major bacteremia sources

 Pneumonia

120 (35.3)

205 (10.2)

<0.001

 Urinary tract infection

39 (11.5)

709 (35.3)

<0.001

 Biliary tract infection

20 (5.9)

200 (10.0)

0.02

 Intra-abdominal infection

47 (13.8)

265 (13.2)

0.75

 Liver abscess

4 (1.2)

75 (3.7)

0.02

 Skin and soft-tissue infection

36 (10.6)

208 (10.4)

0.90

 Primary bacteremia

31 (9.1)

150 (7.5)

0.29

Major comorbidities

 Malignancy

159 (46.8)

500 (24.9)

<0.001

 Hypertension

140 (41.2)

978 (48.7)

0.01

 Diabetes mellitus

117 (34.4)

758 (37.7)

0.24

 Chronic kidney disease

58 (17.1)

361 (18.0)

0.69

 Neurological disease

95 (27.9)

427 (21.3)

0.006

 Liver cirrhosis

70 (20.6)

231 (11.5)

<0.001

Laboratory data on arrival at the ED

 Leukocytes (103/mm3)

14.8 ± 25.7

12.5 ± 7.2

0.11

 Platelet (103/mm3)

162.4 ± 123.1

199.4 ± 114.4

<0.001

 Serum creatinine (mg/dL)

2.4 ± 3.0

2.2 ± 15.3

0.76

 C-reactive protein (mg/L)

162.3 ± 147.5

113.8 ± 118.9

<0.001

  1. ED emergency department, ESBL extended-spectrum beta-lactamase, EKP Escherichia coli, Klebsiella species, and Proteus mirabilis
  2. All variables are expressed as number of cases (%), but laboratory data as mean ± standard deviation