Table 5 Lac influx, efflux, and uptake in cohort 2

Hepatic Lac uptake

Lac ≥10%

10.3 (7.0 to 14.8)

7.8 (5.5 to 15.7)

10.6 (2.3 to 11.4)

15.4 (8.0 to 17.3)

23.0 (8.9 to 26.3)

0.066^b

0.389

0.221

0.754

Lac <10%

12.1 (11.9 to 19.5)

15.0 (10.2 to 22.5)

11.4 (9.3 to 12.7)

7.0 (3.5 to 22.3)

7.5 (6.6 to 11.2)

Hepatic Lac influx

Lac ≥10%

24.8 (19.0 to 30.2)

30.8 (18.8 to 57.8)

23.9 (19.0 to 49.4)

39.4 (13.6 to 47.1)

32.6 (29.0 to 59.6)

0.066^c

Lac <10%

27.1 (19.3 to 45.0)

35.2 (16.5 to 56.5)

25.5 (18.3 to 33.7)

32.5 (17.5 to 45.2)

20.3 (10.1 to 32.5)

0.321^c

Hepatic Lac efflux

Lac ≥10%

12.7 (8.1 to 26.3)

15.0 (5.5 to 52.4)

21.3 (7.7 to 35.9)

26.0 (6.8 to 27.1)

22.1 (10.1 to 30.3)

0.645^b

0.576

0.036

0.560

Lac <10%

12.4 (9.1 to 23.7)

14.7 (4.7 to 38.8)

15.4 (8.1 to 20.9)

19.9 (14.0 to 32.3)

14.3 (3.5 to 21.6)

Gut Lac uptake

Lac ≥10%

−2.6 (−2.9 to 0.3)

−2.2 (−2.8 to −2.1)

−1.7 (−3.9 to 0.3)

−2.4 (−6.8 to 0.5)

−3.8 (−9.9 to −0.6)

0.942^b

0.440

0.779

0.299

Lac <10%

−1.4 (−3.7 to 5.2)

−3.3 (−10.7 to 1.3)

−2.9 (−4.0 to −0.9)

−4.7 (−11.6 to −1.8)

−2.1 (−3.8 to −0.4)

Spleen Lac uptake

Lac ≥10%

−0.2 (−0.7 to −0.2)

−0.2 (−0.6 to −0.1)

−0.2 (−1.1 to −0.1)

−0.1 (−0.9 to −0.1)

0.0 (−0.4 to 0.2)

0.185^b

0.465

0.347

0.911

Lac <10%

−0.1 (−0.3 to 0.1)

−0.1 (−0.3 to 0.1)

−0.3 (−1.6 to −0.1)

−0.1 (−0.7 to 0.0)

−0.1 (−0.2 to 0.0)

Kidney Lac uptake

Lac ≥10%

−0.4 (−1.0 to 0.0)

−1.0 (−1.9 to −0.7)

−0.4 (−2.3 to 0.2)

−0.5 (−2.5 to 1.1)

0.3 (0.1 to 0.9)

0.110^b

0.743

0.546

0.921

Lac <10%

−0.1 (−0.8 to 2.5)

0.4 (−2.0 to 1.7)

−0.6 (−2.1 to 0.2)

−0.2 (−0.7 to 0.4)

−0.4 (−1.0 to 0.3)

Lung Lac uptake

Lac ≥10%

−2.0 (−8.3 to 5.4)

−1.1 (−5.9 to 1.6)

−4.4 (−19.8 to 2.7)

−5.4 (−11.9 to 4.3)

0.0 (−5.4 to 108.3)

0.622^c

Lac <10%

4.8 (−3.0 to 7.2)

−4.1 (−18.3 to 25.7)

−0.1 (−6.5 to 5.4)

−6.5 (−17.8 to 3.2)

−5.6 (−32.2 to 5.3)

0.525^c

Whole-body venous Lac efflux

Lac ≥10%

76.9 (61.6 to 116.3)

84.0 (57.1 to 174.6)

105.4 (93.8 to 162.8)

119.7 (47.6 to 123.6)

104.3 (79.7 to 131.9)

0.635^b

0.144

0.253

0.692

Lac <10%

98.3 (59.2 to 38.6)

107.3 (61.7 to 215.6)

90.2 (76.1 to 109.1)

104.3 (84.3 to 188.1)

110.5 (69.4 to 327.1)

Extrahepatic organ Lac efflux

Lac ≥10%

69.6 (56.5 to 90.0)

59.1 (39.1 to 137.2)

97.0 (72.5 to 117.6)

91.4 (40.2 to 102.4)

82.0 (71.0 to 101.6)

0.346^b

0.077

0.883

0.397

Lac <10%

66.3 (50.0 to 123.5)

92.6 (53.3 to 176.8)

74.8 (61.5 to 94.8)

87.9 (66.8 to 154.6)

102.9 (63.9 to 191.1)