Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Corrêa, Thiago Domingos; Pereira, Adriano José; Brandt, Sebastian; Vuda, Madhusudanarao; Djafarzadeh, Siamak; Takala, Jukka; Jakob, Stephan Mathias

doi:10.1186/s13054-017-1691-4

Critical Care

Table 4 Regional blood flow in cohort 2

From: Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Parameters	Group	BL	3 h	6 h	12 h	End	p value	Time × group p value^a	Time p value^a	Group p value^a
Carotid artery	Lac ≥10%	4.2 ± 0.9	3.8 ± 1.1	3.6 ± 0.5	3.2 ± 0.7	5.7 ± 2.6	0.030^b	0.077	0.458	0.078
	Lac <10%	3.9 ± 0.9	4.1 ± 1.3	4.1 ± 1.4	5.0 ± 2.0	4.9 ± 1.6	0.457^c
	Lac <10%	3.9 ± 0.9	4.1 ± 1.3	4.1 ± 1.4	5.0 ± 2.0	4.9 ± 1.6	0.028^c
Superior mesenteric artery	Lac ≥10%	18.4 ± 8.0	17.7 ± 9.8	17.5 ± 6.6	18.8 ± 9.6	26.6 ± 11.0	0.010^b	0.858	0.179	0.807
Superior mesenteric artery	Lac <10%	13.7 ± 2.9	15.7 ± 3.1	16.6 ± 3.4	18.2 ± 4.1	15.3 ± 7.6	0.028^c	0.858	0.179	0.807
Celiac trunk	Lac ≥10%	9.2 ± 4.6	10.8 ± 3.4	9.8 ± 4.4	12.5 ± 3.9	11.8 ± 5.9	0.191^b	0.067	0.221	0.067
Celiac trunk	Lac <10%	8.8 ± 3.7	9.2 ± 4.1	9.9 ± 4.2	9.3 ± 5.0	7.0 ± 2.1		0.067	0.221	0.067
Hepatic artery	Lac ≥10%	4.2 ± 3.7	5.2 ± 2.9	5.0 ± 3.0	6.3 ± 3.6	5.5 ± 2.6	0.232^b	0.100	0.149	0.142
Hepatic artery	Lac <10%	3.7 ± 1.8	3.0 ± 1.6	3.7 ± 1.8	3.6 ± 2.3	2.5 ± 0.9		0.100	0.149	0.142
Portal vein	Lac ≥10%	20.5 ± 7.0	20.5 ± 11.5	19.2 ± 6.7	20.5 ± 8.4	27.4 ± 11.6	0.006^b	0.717	0.408	0.488
Portal vein	Lac <10%	19.3 ± 5.4	22.3 ± 5.6	21.8 ± 4.3	22.3 ± 6.0	17.3 ± 10.0	0.083^c	0.717	0.408	0.488
Total hepatic^d	Lac ≥10%	24.8 ± 8.2	25.7 ± 12.1	24.2 ± 8.0	26.8 ± 9.4	32.8 ± 13.0	0.006^b	0.371	0.224	0.965
Total hepatic^d	Lac <10%	23.0 ± 5.4	25.3 ± 6.1	25.4 ± 4.7	25.9 ± 7.8	19.8 ± 10.1	0.040^c	0.371	0.224	0.965
Spleen artery	Lac ≥10%	1.1 ± 0.4	1.1 ± 1.1	1.0 ± 0.8	1.2 ± 1.0	1.2 ± 1.2	0.049^b	0.115	0.341	0.766
Spleen artery	Lac <10%	1.1 ± 0.3	1.5 ± 1.2	1.3 ± 0.8	1.2 ± 1.0	0.5 ± 0.2	0.167^c	0.115	0.341	0.766
Renal artery	Lac ≥10%	5.2 ± 1.9	5.1 ± 1.4	4.4 ± 1.0	5.0 ± 1.0	3.9 ± 1.3	0.036^b	0.059	0.409	0.782
Renal artery	Lac <10%	5.8 ± 2.0	5.4 ± 2.1	5.7 ± 2.9	4.3 ± 2.7	2.1 ± 1.4	0.018^c	0.059	0.409	0.782

BL baseline, End End of experiment after 24 h of randomization or before death, if earlier
Values represent mean ± SD. All flows are in milliliters per kilogram per minute
^a p Values were calculated with repeated-measures analysis of variance including time points 6 h and 12 h for time × group interaction, time effect, and group effect
^bTime × group interaction with repeated-measures analysis of variance including all time points
^cIndependent-samples t test at end of study
^dSum of hepatic artery and portal vein blood flows

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