Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Corrêa, Thiago Domingos; Pereira, Adriano José; Brandt, Sebastian; Vuda, Madhusudanarao; Djafarzadeh, Siamak; Takala, Jukka; Jakob, Stephan Mathias

doi:10.1186/s13054-017-1691-4

Critical Care

Table 2 Hemodynamics and arterial lactate levels in cohort 1

From: Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Parameters	Group	BL	BR	RP 6 h	End	p Value
Heart rate, beats/minute	Lac ≥10%	94 ± 20	160 ± 40	165 ± 26	132 ± 34	0.369^a
Heart rate, beats/minute	Lac <10%	97 ± 17	166 ± 30	161 ± 34	154 ± 33	0.369^a
MAP, mmHg	Lac ≥10%	85 ± 12	75 ± 11	82 ± 13	65 ± 10	0.113^a
MAP, mmHg	Lac <10%	88 ± 13	77 ± 19	71 ± 12	56 ± 20	0.113^a
MPAP, mmHg	Lac ≥10%	14 ± 3	17 ± 3	17 ± 3	21 ± 5	0.594^a
MPAP, mmHg	Lac <10%	15 ± 6	17 ± 5	20 ± 6	22 ± 4	0.594^a
CVP, mmHg	Lac ≥10%	4 ± 1	3 ± 2	3 ± 2	7 ± 2	0.632^a
CVP, mmHg	Lac <10%	5 ± 3	2 ± 2	3 ± 2	8 ± 4	0.632^a
Cardiac output, ml/kg/minute	Lac ≥10%	131 ± 14	106 ± 16	120 ± 20	151 ± 32	0.618^a
Cardiac output, ml/kg/minute	Lac <10%	132 ± 22	119 ± 33	122 ± 24	144 ± 46	0.618^a
SVRI, mmHg, L/kg/minute	Lac ≥10%	629 ± 112	696 ± 146	677 ± 154	393 ± 92	0.322^a
SVRI, mmHg, L/kg/minute	Lac <10%	654 ± 171	652 ± 164	575 ± 164	326 ± 73	0.322^a
SvO₂, %	Lac ≥10%	55 ± 8	59 ± 11	64 ± 9	63 ± 12	0.264^a
SvO₂, %	Lac <10%	53 ± 9	57 ± 6	60 ± 6	52 ± 18	0.264^a
DO₂, ml/minute	Lac ≥10%	625 ± 99	684 ± 116	739 ± 76	653 ± 151	0.796^a
DO₂, ml/minute	Lac <10%	610 ± 148	702 ± 133	697 ± 156	609 ± 197	0.796^a
VO₂, ml/minute	Lac ≥10%	273 ± 63	270 ± 86	249 ± 79	220 ± 81	0.987^a
VO₂, ml/minute	Lac <10%	275 ± 61	281 ± 48	256 ± 60	234 ± 59	0.987^a
O₂ER	Lac ≥10%	0.44 ± 0.08	0.40 ± 0.11	0.34 ± 0.10	0.34 ± 0.13	0.511^a
O₂ER	Lac <10%	0.46 ± 0.09	0.41 ± 0.05	0.37 ± 0.06	0.43 ± 0.18	0.511^a
Fractional carotid artery blood flow, %	Lac ≥10%	5.8 ± 1.9	4.7 ± 1.8	4.6 ± 1.5	4.4 ± 1.5	0.340^a
Fractional carotid artery blood flow, %	Lac <10%	5.8 ± 1.2	5.4 ± 1.3	5.6 ± 1.3	5.0 ± 2.0	0.340^a
Fractional femoral artery blood flow, %	Lac ≥10%	3.3 ± 1.1	2.0 ± 0.5	1.7 ± 0.5	1.9 ± 0.5	0.499^a
Fractional femoral artery blood flow, %	Lac <10%	3.3 ± 0.8	2.1 ± 0.7	2.2 ± 0.9	2.1 ± 0.8	0.499^a
Arterial Lac, mmol/L	Lac ≥10%	0.8 ± 0.1	1.4 ± 0.7	1.1 ± 0.6	1.1 ± 0.7	0.124^a
Arterial Lac, mmol/L	Lac <10%	0.9 ± 0.3	1.6 ± 1.2	1.9 ± 1.4	2.3 ± 2.5	0.124^a

Abbreviations: BL Baseline, BR Immediately before start resuscitation, RP Resuscitation period, End End of the experiment (at 48 h of resuscitation or before death if earlier), MAP Mean arterial blood pressure, MPAP Mean pulmonary arterial pressure, CVP Central venous pressure, SVRI Systemic vascular resistance index, SvO ₂ Mixed venous oxygen saturation, DO ₂ Oxygen delivery, VO ₂ Oxygen consumption, O ₂ ER Oxygen extraction ratio
Values represent mean ± SD
^aTime × group interaction with repeated-measures analysis of variance including all time points

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