Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

Table 1 Administered treatment, fluid output, and balance in cohort 1 study

Parameters	Lac ≥10%	Lac <10%	p value
Propofol, mg/kg/h	5.7 (5.1–6.2)	5.5 (4.9–5.9)	0.459^a
Fentanyl^b, μg/kg/h	4.9 (4.5–5.7)	5.2 (5.0–8.1)	0.072^a
Midazolam, mg/kg/h	0.05 (0.04–0.06)	0.06 (0.05–00.7)	0.331^a
Fluid bolus^c,d, ml/kg/h	0.80 (0.53–1.24)	1.68 (0.50–2.82)	0.186^a
Ringer’s lactate	0.45 (0.30–0.65)	0.84 (0.28–1.75)	0.186^a
HES	0.39 (0.23–0.58	0.84 (0.21–1.07)	0.150^a
Norepinephrine
n/Total n, %	7/13 (53.8)	8/11 (72.7)	0.423^e
Dose, μg/kg/minute	0.02 (0.01–0.07)	0.10 (0.06–0.22)	0.054^a
Dobutamine
n/Total n, %	2/13 (15.4)	5/11 (45.5)	0.182^e
Dose, μg/kg/minute	1.89 (0.65–3.13)	0.44 (0.33–0.58)	0.190^a
Total volume received^f, ml/kg/h	3.61 (3.49–4.11)	4.12 (3.43–5.39)	0.303^a
Urine output, ml/kg/h	1.00 (0.96–1.15)	1.21 (0.99–1.36)	0.134^a
Gastric tube output, ml/kg/h	0.22 (0.05–0.30)	0.42 (0.22–0.71)	0.036^a
Final balance^g, ml/kg/h	2.48 (2.15–2.75)	2.45 (1.93–4.13)	1.000^a

HES 6% Hydroxyethyl starch 130/0.4, Lac Lactate
Values are median (IQR) or n/total n (%) when indicated
^aMann-Whitney U test
^bSum of basic fentanyl infusion with additional bolus
^cSum of Ringer’s lactate and HES
^dAdministered during resuscitation period
^eFisher’s exact test
^fSum of Ringer’s lactate basal infusion + 50% glucose basal infusion + Ringer’s lactate bolus + HES
^gFinal balance = total volume received − (urine output + gastric tube output)

ISSN: 1364-8535