Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Univariable and multivariable analysis of factors associated with hospital mortality in ventilated patients with ARDS

From: Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany

Variable Univariable analysisa Multivariable analysisb
Odds ratio (95% CI) p value Odds ratio (95% CI) p value
Factors related to patients’ baseline factors
 Sex   0.068   
  Male 1.82 (0.96–3.46)    
  Female 1    
 SAPS II at ICU admission   0.005   
  ≤40 1    
  40–59 2.09 (1.03–4.22)    
  ≥60 3.69 (1.64–8.29)    
Factors related to individual patient management
 FiO2 (0.1 increments) 1.79 (1.35–2.38) <0.001 1.62 (1.17–2.24) 0.004
 Driving pressurec (1 cmH2O increments) 1.17 (1.08–1.26) <0.001 1.10 (1.02–1.20) 0.016
 Use of vasoactive drugs (2 consecutive days) 2.01 (1.00–4.02) 0.049   
Factors developing during mechanical ventilation
 Liver failure 7.85 (2.24–27.55) 0.001 6.93 (1.68–28.59) 0.007
 Renal failure 4.15 (2.25–7.64) <0.001 3.46 (1.59–7.55) 0.002
 Metabolic acidosis 3.29 (1.48–7.29) 0.003 2.94 (1.03–8.27) 0.043
 pHa   0.001   
  Acidosis (<7.35) 4.09 (1.90–8.77)    
  7.35–7.45 1    
  Alkalosis (>7.45) 1.17 (0.55–2.47)    
 Lowest PaO2/FiO2 (mmHg)   0.009   
  ≤100 3.08 (1.38–6.85)    
  100–150 2.53 (1.26–5.10)    
  >150 1    
Factors related to the setting of care
 Non-university hospital 2.10 (1.17–3.75) 0.013 2.89 (1.31–6.38) 0.008
 University hospital 1   1  
  1. ARDS acute respiratory distress syndrome, CI confidence interval, SAPS II Severe Acute Physiology Score II, ICU intensive care unit, FiO 2 fraction of inspired oxygen, PaO 2 partial pressure of arterial oxygen tension, PEEP positive end-expiratory pressure
  2. aOnly those variables are shown that qualified with p < 0.1 in the four prior multivariate analyses within the four variable categories for the overall final multivariable model (as described in Methods and in Additional file 1, the other variables in each category including tidal volume, PEEP, hospital size, ICU size and case volume of ventilated patients per ICU were eliminated in the multivariate analysis within each category by the presented parameters and did not qualify for the final model)
  3. bOnly those variables are shown that remained significant in the final multivariable model for n = 169 with stepwise backward elimination using a threshold of p = 0.05 according to Wald statistics. Goodness of fit: Hosmer–Lemeshow test, p = 0.398; area under the receiver-operator curve, 0.84 (95% CI 0.78–0.90), p < 0.001
  4. cDriving pressure = plateau pressure – PEEP