Table 2 Univariable and multivariable analysis of factors associated with hospital mortality in ventilated patients with ARDS

 Sex

0.068

  Male

1.82 (0.96–3.46)

  Female

1

 SAPS II at ICU admission

0.005

  ≤40

1

  40–59

2.09 (1.03–4.22)

  ≥60

3.69 (1.64–8.29)

 FiO₂ (0.1 increments)

1.79 (1.35–2.38)

<0.001

1.62 (1.17–2.24)

0.004

 Driving pressure^c (1 cmH₂O increments)

1.17 (1.08–1.26)

<0.001

1.10 (1.02–1.20)

0.016

 Use of vasoactive drugs (2 consecutive days)

2.01 (1.00–4.02)

0.049

 Liver failure

7.85 (2.24–27.55)

0.001

6.93 (1.68–28.59)

0.007

 Renal failure

4.15 (2.25–7.64)

<0.001

3.46 (1.59–7.55)

0.002

 Metabolic acidosis

3.29 (1.48–7.29)

0.003

2.94 (1.03–8.27)

0.043

 pHa

0.001

  Acidosis (<7.35)

4.09 (1.90–8.77)

  7.35–7.45

1

  Alkalosis (>7.45)

1.17 (0.55–2.47)

 Lowest PaO₂/FiO₂ (mmHg)

0.009

  ≤100

3.08 (1.38–6.85)

  100–150

2.53 (1.26–5.10)

  >150

1

 Non-university hospital

2.10 (1.17–3.75)

0.013

2.89 (1.31–6.38)

0.008

 University hospital

1

1