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Table 1 Demographic and clinical characteristics at onset of ARDS in university and non-university hospitals

From: Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany

  University hospital Non-university hospital  
(n = 87) (n = 111) p value
Age (years) 59.0 (16.2); 63 (47–72) 62.8 (15.9); 65 (52–74) 0.10
Sex, male/female 62 (71.3)/25 (28.7) 80 (72.1)/31 (27.9) 0.9
BMI (kg/m2) 26.0 (4.9); 25.7 (23.2–27.7) 26.9 (6.2); 26.0 (23.1–29.4) 0.34
BMI categories
 < 18.5/<25.5/<30.0/≥30.0 kg/m2 3 (4.5)/28 (41.8)/28 (41.8)/8 (11.9) 5 (4.7)/39 (36.8)/41 (38.7)/21(19.8) 0.6
SAPS II at ICU admission 45.2 (17.2); 42 (32–58) 48.7 (20.4); 48 (37–62) 0.21
Main problem, medical/surgical 48 (55.2)/39 (44.8) 69 (62.2)/42 (37.8) 0.32
ARDS origin, pulmonary/ extrapulmonary 65 (78.3)/18 (21.7) 79 (72.5)/30 (27.5) 0.36
Late onset of ARDSa 35 (40.2) 28 (25.2) 0.02
Onset of ARDS: day after initiation of mechanical ventilation 1 (0-5) 0 (0-2) 0.02
PaO2/FiO2 (mmHg) 157 (124-186) 149 (114-179) 0.29
Dynamic complianceb (ml/mbar; ml/mbar/kg PBW) 39 (29–55); 0.58 (0.44–0.79) 33 (24–43); 0.52 (0.39–0.67) 0.006; 0.04
Reason for initiation of mechanical ventilation (only presented when different between groups)c
 Postoperative acute respiratory failure 19 (21.8) 12 (10.8) 0.03
 Acute respiratory failure after aspiration 2 (2.3) 12 (10.8) 0.02
Complications until the onset of ARDS
 Sepsisc 41 (47.1) 38 (34.2) 0.07
 Pneumoniac 43 (49.4) 44 (39.6) 0.17
 Cardiovascular failure 63 (72.4) 71 (64.0) 0.21
 Renal failure 26 (29.9) 32 (28.8) 0.87
 Coagulopathy 23 (26.4) 8 (7.2) <0.001
 Liver failure 11 (12.6) 2 (1.8) 0.002
 Metabolic acidosis 8 (9.2) 13 (11.7) 0.57
 Respiratory acidosis 18 (20.7) 23 (20.7) 1.0
 Barotrauma 14 (16.1) 13 (11.7) 0.37
  1. Data presented as mean (standard deviation); median (interquartile range) or n (%)
  2. ARDS acute respiratory distress syndrome, BMI body mass index, SAPS II Severe Acute Physiology Score II, ICU intensive care unit, PaO 2 /FiO 2 arterial-to-inspired oxygen ratio, PBW predicted body weight, PEEP positive end-expiratory pressure
  3. aDefined as ARDS developing ≥48 h after the onset of mechanical ventilation
  4. bCompliance = tidal volume / (plateau pressure – PEEP)
  5. cAll cases as reason for initiation of mechanical ventilation or developing as complication during mechanical ventilation until the onset of ARDS. The other reasons for the initiation of mechanical ventilation did not differ between ARDS patients in university and non-university hospitals (e.g., multiple trauma, eight vs five patients (9.2 vs 4.5%), p = 0.19). Further details for these other reasons for the entire group of patients with ARDS are presented in Additional file 1: Table S1