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Table 2 Main symptoms of cytokine-release syndrome

From: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

Constitutional  
 Fever, chills, headache, asthenia, myalgia, arthralgia, back or abdominal pain  
Organ related  
 Oliguria, bronchospasm, dyspnea, hypotension, tachycardia, arrhythmia, confusion, erythema, urticarial reaction, pruritus  
Lab tests  
 Hypokalemia, increased urea, decreased glomerular filtration rate, altered blood counts and/or coagulation tests, elevation of C-reactive protein and/or procalcitonin