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Table 2 Main symptoms of cytokine-release syndrome

From: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

Constitutional

 

 Fever, chills, headache, asthenia, myalgia, arthralgia, back or abdominal pain

 

Organ related

 

 Oliguria, bronchospasm, dyspnea, hypotension, tachycardia, arrhythmia, confusion, erythema, urticarial reaction, pruritus

 

Lab tests

 

 Hypokalemia, increased urea, decreased glomerular filtration rate, altered blood counts and/or coagulation tests, elevation of C-reactive protein and/or procalcitonin

 
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Critical Care

ISSN: 1364-8535