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Table 3 Associations between cardiac troponin I, cardiac troponin T and NT-proBNP and odds of maximum stage of AKI – excluding patients with confirmed MI

From: Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis

Parameter

Number of patients

Median (IQR)

Median (IQR)

ORa (95% CI)

p value

Adjustedb ORa (95% CI)

Adjustedb p value

 

(1)

(2)

(1)

(2)

    

Cardiac troponin I

 Any AKI (1) vs no AKI (2)

62

56

0.12 (0.04–0.69)

0.02 (0.02–0.06)

1.50 (1.22–1.85)

<0.001

1.31 (1.05–1.63)

0.015

 Stage 3 AKI (1) vs lower stage (2)

40

78

0.17 (0.05–1.03)

0.03 (0.02–0.08)

1.41 (1.19–1.68)

<0.001

1.25 (1.01–1.56)

0.043

 Stage 3 AKI with RRT (1) vs lower stage (2)

34

84

0.17 (0.05–1.08)

0.04 (0.02–0.12)

1.35 (1.14–1.60)

0.001

1.12 (0.93–1.45)

0.199

Cardiac troponin T

 Any AKI (1) vs no AKI (2)

62

56

0.07 (0.03–0.15)

0.02 (0.01–0.04)

1.83 (1.42–2.35)

<0.001

1.55 (1.16–2.07)

0.003

 Stage 3 AKI (1) vs lower stage (2)

40

78

0.08 (0.04–0.19)

0.03 (0.01–0.06

1.69 (1.32–2.15)

<0.001

1.51 (1.10–2.09)

0.012

 Stage 3 AKI with RRT (1) vs lower stage (2)

34

84

0.08 (0.05–0.18)

0.03 (0.01–0.07)

1.55 (1.23–1.96)

<0.001

1.31 (0.94–1.84)

0.109

NT-proBNP

 Any AKI (1) vs no AKI (2)

62

56

7182 (2314–15,550)

1055 (192–2944)

1.47 (1.24–1.74)

<0.001

1.31 (1.06–1.61)

0.012

 Stage 3 AKI (1) vs lower stage (2)

40

78

9179 (2561–16,179)

1609 (320–6015)

1.49 (1.23–1.81)

<0.001

1.45 (1.12–1.86)

0.004

 Stage 3 AKI with RRT (1) vs lower stage (2)

34

84

10,105 (2617–17,069)

1681 (490–6416)

1.48 (1.21–1.81)

<0.001

1.43 (1.09–1.88)

0.011

  1. AKI acute kidney injury, RRT renal replacement therapy, IQR interquartile range, CI confidence interval, MI myocardial infarction, NT-proBNP N-terminal pro-brain natriuretic peptide, OR odds ratio, APACHE Acute Physiology and Chronic Health Evaluation
  2. aORs estimated using logistic regression models with troponin levels log2 transformed. ORs represent the change in odds of AKI associated with a doubling of troponin levels
  3. bAdjusted for age, APACHE II score, gender, hypertension, diabetes, ischaemic heart disease, sepsis, lactate, bilirubin and cumulative fluid balance in the first 24 hours in the ICU (reduced to three principal components in models)