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Table 3 Associations between cardiac troponin I, cardiac troponin T and NT-proBNP and odds of maximum stage of AKI – excluding patients with confirmed MI

From: Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis

Parameter Number of patients Median (IQR) Median (IQR) ORa (95% CI) p value Adjustedb ORa (95% CI) Adjustedb p value
  (1) (2) (1) (2)     
Cardiac troponin I
 Any AKI (1) vs no AKI (2) 62 56 0.12 (0.04–0.69) 0.02 (0.02–0.06) 1.50 (1.22–1.85) <0.001 1.31 (1.05–1.63) 0.015
 Stage 3 AKI (1) vs lower stage (2) 40 78 0.17 (0.05–1.03) 0.03 (0.02–0.08) 1.41 (1.19–1.68) <0.001 1.25 (1.01–1.56) 0.043
 Stage 3 AKI with RRT (1) vs lower stage (2) 34 84 0.17 (0.05–1.08) 0.04 (0.02–0.12) 1.35 (1.14–1.60) 0.001 1.12 (0.93–1.45) 0.199
Cardiac troponin T
 Any AKI (1) vs no AKI (2) 62 56 0.07 (0.03–0.15) 0.02 (0.01–0.04) 1.83 (1.42–2.35) <0.001 1.55 (1.16–2.07) 0.003
 Stage 3 AKI (1) vs lower stage (2) 40 78 0.08 (0.04–0.19) 0.03 (0.01–0.06 1.69 (1.32–2.15) <0.001 1.51 (1.10–2.09) 0.012
 Stage 3 AKI with RRT (1) vs lower stage (2) 34 84 0.08 (0.05–0.18) 0.03 (0.01–0.07) 1.55 (1.23–1.96) <0.001 1.31 (0.94–1.84) 0.109
NT-proBNP
 Any AKI (1) vs no AKI (2) 62 56 7182 (2314–15,550) 1055 (192–2944) 1.47 (1.24–1.74) <0.001 1.31 (1.06–1.61) 0.012
 Stage 3 AKI (1) vs lower stage (2) 40 78 9179 (2561–16,179) 1609 (320–6015) 1.49 (1.23–1.81) <0.001 1.45 (1.12–1.86) 0.004
 Stage 3 AKI with RRT (1) vs lower stage (2) 34 84 10,105 (2617–17,069) 1681 (490–6416) 1.48 (1.21–1.81) <0.001 1.43 (1.09–1.88) 0.011
  1. AKI acute kidney injury, RRT renal replacement therapy, IQR interquartile range, CI confidence interval, MI myocardial infarction, NT-proBNP N-terminal pro-brain natriuretic peptide, OR odds ratio, APACHE Acute Physiology and Chronic Health Evaluation
  2. aORs estimated using logistic regression models with troponin levels log2 transformed. ORs represent the change in odds of AKI associated with a doubling of troponin levels
  3. bAdjusted for age, APACHE II score, gender, hypertension, diabetes, ischaemic heart disease, sepsis, lactate, bilirubin and cumulative fluid balance in the first 24 hours in the ICU (reduced to three principal components in models)