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Table 2 Associations between cardiac troponin I, cardiac troponin T and NT-proBNP and maximum stage of AKI

From: Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis

Cardiac biomarker Median (IQR), Median (IQR), Unadjusted ORa (95% CI) p value Adjustedb ORa (95% CI) Adjusteda p value
  Group 1 Group 2     
Cardiac troponin I
 Any AKI (1) vs no AKI (2) 0.14 (0.04–0.70) 0.03 (0.02–1.0) 1.37 (1.16–1.62) <0.001 1.20 (1.00–1.45) 0.044
 Stage 3 AKI (1) vs lower stage (2) 0.22 (0.06 –1.03) 0.04 (0.02–0.16) 1.33 (1.14–1.54) <0.001 1.17 (0.98–1.41) 0.085
 Stage 3 AKI with RRT (1) vs lower stage (2) 0.27 (0.06–1.03) 0.04 (0.02–0.19) 1.27 (1.10–1.40) 0.001 1.09 (0.90–1.32) 0.376
Cardiac troponin T
 Any AKI (1) vs no AKI (2) 0.07 (0.04–0.16) 0.02 (0.01–0.05) 1.63 (1.32–2.01) <0.001 1.36 (1.06–1.74) 0.014
 Stage 3 AKI (1) vs lower stage (2) 0.10 (0.05–0.21) 0.03 (0.01–0.07) 1.58 (1.28–1.96) <0.001 1.40 (1.06–1.84) 0.018
 Stage 3 AKI with RRT (1) vs lower stage (2) 0.10 (0.05–0.21) 0.03 (0.01–0.08) 1.49 (1.21–1.83) <0.001 1.27 (0.95–1.69) 0.104
NT-proBNP
 Any AKI (1) vs no AKI (2) 8888 (2504–18685) 1543 (239–5301) 1.41 (1.22–1.64) <0.001 1.23 (1.02–1.47) 0.027
 Stage 3 AKI (1) vs lower stage (2) 10879 (2792–19797) 1609 (480–7055) 1.52 (1.27–1.82) <0.001 1.44 (1.14–1.82) 0.002
 Stage 3 AKI with RRT (1) vs lower stage (2) 11302 (2792–21512) 1718 (531–7293) 1.48 (1.22–1.78) <0.001 1.40 (1.09–1.81) 0.008
  1. NT-proBNP N-terminal pro-brain natriuretic peptide, AKI acute kidney injury, RRT renal replacement therapy, IQR interquartile range, CI confidence interval, OR odds ratio, APACHE Acute Physiology and Chronic Health Evaluation
  2. aORs estimated using logistic regression models with troponin levels log2 transformed. ORs represent the change in odds of AKI associated with a doubling of troponin levels
  3. bAdjusted for age, APACHE II score, gender, hypertension, diabetes, ischaemic heart disease, sepsis, lactate, bilirubin and cumulative fluid balance in the first 24 hours in the ICU (reduced to three principal components in models)