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Table 5 Top biological pathways based on identified metabolites involved for diagnosis of and prognosis of H1N1

From: Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

MetaboAnalyst
Pathway analysis
NMR GC-MSa
Diagnosis of H1N1 Pneumonia from Positive Bacterial Culture Pneumonia - Synthesis and degradation of ketone bodies
- Beta-alanine metabolism
- Glycine, serine and threonine metabolism
- Methane metabolism
- Glyoxylate and dicarboxylate metabolism
- Histidine metabolism
- Lysine degradation
- Inositol phosphate metabolism
Diagnosis of H1N1 Pneumonia from Ventilated ICU Controls - Taurine and hypotaurine metabolism
- Glycine, serine and threonine
- Beta-Alanine metabolism
- Citrate cycle (TCA cycle)
- Glyoxylate and dicarboxylate metabolism
- Phenylalanine metabolism
- Galactose metabolism
- Glycine, serine and threonine metabolism
- Pyruvate metabolism
- Phenylalanine metabolism
Prognosis of mortality of H1N1 pneumonia (separation nonsurvivors from survivors) - Synthesis and degradation of ketone bodies
- Arginine and Ornithine metabolism
- Arginine and Proline metabolism
- Phenylalanine metabolism
- Citrate cycle (TCA cycle)
- Beta-Alanine metabolism
- Galactose metabolism
- Alanine, Aspartate and glutamate metabolism
- Glycerolipid metabolism
- Pyruvate metabolism and glycolysis or glycogenesis
  1. aTop biological pathways obtained using the knowns features