Table 5 Top biological pathways based on identified metabolites involved for diagnosis of and prognosis of H1N1
From: Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
MetaboAnalyst Pathway analysis | NMR | GC-MSa |
|---|---|---|
Diagnosis of H1N1 Pneumonia from Positive Bacterial Culture Pneumonia | - Synthesis and degradation of ketone bodies - Beta-alanine metabolism - Glycine, serine and threonine metabolism - Methane metabolism - Glyoxylate and dicarboxylate metabolism - Histidine metabolism | - Lysine degradation - Inositol phosphate metabolism |
Diagnosis of H1N1 Pneumonia from Ventilated ICU Controls | - Taurine and hypotaurine metabolism - Glycine, serine and threonine - Beta-Alanine metabolism - Citrate cycle (TCA cycle) - Glyoxylate and dicarboxylate metabolism - Phenylalanine metabolism | - Galactose metabolism - Glycine, serine and threonine metabolism - Pyruvate metabolism - Phenylalanine metabolism |
Prognosis of mortality of H1N1 pneumonia (separation nonsurvivors from survivors) | - Synthesis and degradation of ketone bodies - Arginine and Ornithine metabolism - Arginine and Proline metabolism - Phenylalanine metabolism - Citrate cycle (TCA cycle) | - Beta-Alanine metabolism - Galactose metabolism - Alanine, Aspartate and glutamate metabolism - Glycerolipid metabolism - Pyruvate metabolism and glycolysis or glycogenesis |