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Table 3 Summary of discrimination (OPLS-DA) modeling statistics for the diagnostic and prognosis of H1N1

From: Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

Analytical tool R2Y Q2Y P value Sensitivity Specificity AUROC Metabolites/features
Discrimination (OPLS-DA) models for differentiation of H1N1 (n = 29) from sex-matched positive bacterial culture CAP samples (n = 29)
 NMR 0.825 0.589 <0.0001 87 100 0.908 50
 GC-MS 0.937 0.879 <0.0001 100 100 0.942 70 (known)
Discrimination (OPLS-DA) models for differentiation of H1N1 (n = 42) from age- and sex-matched ICU controls (n = 31)
 NMR 0.889 0.789 <0.0001 100 100 0.921 55
 GC-MS 0.981 0.971 <0.0001 100 100 0.959 68 (37 known)
Discrimination (OPLS-DA) models for prognosis of 90-day mortality in H1N1 (non-survivors (n = 7) vs. age- and sex-matched survivors (n = 14)
 NMR 0.831 0.597 0.004 100 100 0.865 20
 GC-MS 0.909 0.829 0.0001 100 100 0.909 63 (32 known)