Table 3 Summary of discrimination (OPLS-DA) modeling statistics for the diagnostic and prognosis of H1N1
From: Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
Analytical tool | R2Y | Q2Y | P value | Sensitivity | Specificity | AUROC | Metabolites/features |
|---|---|---|---|---|---|---|---|
Discrimination (OPLS-DA) models for differentiation of H1N1 (n = 29) from sex-matched positive bacterial culture CAP samples (n = 29) | |||||||
 NMR | 0.825 | 0.589 | <0.0001 | 87 | 100 | 0.908 | 50 |
 GC-MS | 0.937 | 0.879 | <0.0001 | 100 | 100 | 0.942 | 70 (known) |
Discrimination (OPLS-DA) models for differentiation of H1N1 (n = 42) from age- and sex-matched ICU controls (n = 31) | |||||||
 NMR | 0.889 | 0.789 | <0.0001 | 100 | 100 | 0.921 | 55 |
 GC-MS | 0.981 | 0.971 | <0.0001 | 100 | 100 | 0.959 | 68 (37 known) |
Discrimination (OPLS-DA) models for prognosis of 90-day mortality in H1N1 (non-survivors (n = 7) vs. age- and sex-matched survivors (n = 14) | |||||||
 NMR | 0.831 | 0.597 | 0.004 | 100 | 100 | 0.865 | 20 |
 GC-MS | 0.909 | 0.829 | 0.0001 | 100 | 100 | 0.909 | 63 (32 known) |