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Table 1 Proposed elements for CRRT pharmacokinetic assessment

From: The future of critical care: renal support in 2027

• Estimation of pharmacokinetic parameters, including variability

• Comparison of pharmacokinetic parameters with those of typical patients with normal kidney function (literature or sponsor data) or the appropriate reference population

• Quantification of the impact of changes in the prescribed Q e on the pharmacokinetic parameters of interest, and interpolation for flow rates not evaluated in this study

• Assessment of whether dosage adjustment is warranted in CRRT recipients

• If dosage adjustment is warranted, derivation of specific dosing recommendations for the studied conditions

  1. Reprinted with permission from [45]
  2. CRRT continuous renal replacement therapy
  3. Q e - effluent rate (ml/hr)