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Table 2 Sensitivity and specificity at different thresholds for qSOFA and SIRS for various clinical outcomes of included patients

From: Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

Variable qSOFA SIRS
  ≥1 ≥2 ≥3 ≥1 ≥2 ≥3 ≥4
In-hospital mortality
 Sensitivity, % (95% CI)a 100 (88–100) 90 (73–98) 48 (29–68) 100 (88–100) 93 (77–99) 83 (64–92) 31 (15–51)
 Specificity, % (95% CI)a 7 (3–13) 42 (33–52) 86 (79–92) 0 (0–3) 12 (7–19) 37 (28–46) 76 (67–83)
ICU-free daysb
 Sensitivity, % (95% CI) 99 (92–100) 76 (65–86) 28 (18–40) 100 (95–100) 92 (83–97) 71 (59–81) 26 (17–38)
 Specificity, % (95% CI) 10 (4–18) 48 (36–59) 86 (77–93) 0 (0–5) 14 (7–23) 36 (26–48) 75 (64–84)
Ventilator-free daysb
 Sensitivity, % (95% CI) 99 (93–100) 74 (62–83) 29 (19–41) 100 (95–100) 93 (85–98) 72 (60–82) 29 (19–41)
 Specificity, % (95% CI) 10 (4–19) 45 (34–57) 88 (78–94) 0 (0–5) 15 (8–25) 38 (27–49) 78 (67–86)
Any organ dysfunction-free daysb
 Sensitivity, % (95% CI) 96 (89–99) 68 (57–79) 28 (18–39) 100 (95–100) 89 (80–95) 68 (57–79) 25 (16–36)
 Specificity, % (95% CI) 8 (3–16) 41 (30–53) 87 (77–94) 0 (0–5) 12 (6–21) 34 (24–46) 74 (62–83)
Renal dysfunction-free daysb
 Sensitivity, % (95% CI) 95 (87–99) 70 (58–80) 26 (17–38) 100 (95–100) 88 (79–94) 68 (57–79) 26 (17–38)
 Specificity, % (95% CI) 7 (2–15) 42 (31–54) 86 (76–93) 0 (0–5) 11 (5–20) 34 (24–46) 75 (64–84)
  1. Abbreviations: qSOFA quick Sequential (Sepsis-related) Organ Failure Assessment, SIRS Systemic Inflammatory Response Syndrome, ICU intensive care unit, CI confidence intervals
  2. aSensitivity was calculated on the basis of the number of participants who experienced the clinical outcome. Specificity was calculated on the basis of the number of participants who did not experience the clinical outcome
  3. bClinical outcomes other than in-hospital mortality (namely, ICU-free days, ventilator-free days, any organ dysfunction-free days, and renal dysfunction-free days) were considered as categorical variables with the median of the entire cohort serving as the threshold. The median of the entire cohort for ICU-free days, ventilator-free days, any organ dysfunction-free days, and renal dysfunction-free days was 22, 28, 5, and 14 days, respectively. Thus, the sensitivity and specificity for ICU-free days <22, ventilator-free days <28, any organ dysfunction-free days <5, and renal dysfunction-free days <14 were calculated