Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study

Table 3 Association of admission glucocorticoid levels with short-term adverse outcome in community-acquired pneumonia

Entire cohort (N = 285)	Adverse outcome at 30 days (death and/or ICU admission)
	OR (95% CI)	p Value
Cortisol
Logistic regression analyses
Univariate model	4.16 (95% CI 1.22–14.12)	0.022
Multivariate model^a	3.85 (95% CI 1.10–13.49)	0.035
11-Deoxycortisol
Logistic regression analyses
Univariate model	1.33 (95% CI 0.84–2.11)	0.216
Multivariate model^a	1.30 (95% CI 0.80–2.14)	0.293
Cortisone
Logistic regression analyses
Univariate model	1.89 (95% CI 0.59–1.03)	0.280
Multivariate model^a	3.25 (95% CI 0.84–12.68)	0.089
Corticosterone
Logistic regression analyses
Univariate model	1.41 (95% CI 0.81–2.47)	0.225
Multivariate model^a	1.44 (95% CI 0.79–2.62)	0.234

ICU, Intensive care unit
Data for univariate and multivariate logistic regression models are presented as OR (95% CI), p value; p < 0.05 is considered statistically significant. Bold values indicate statistical significance. All hormone levels were log-transformed, and thus the OR corresponds to a tenfold increase in levels
^aMultivariate model is adjusted for age, sex, and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)

ISSN: 1364-8535