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Table 3 Diagnostic tests and their utility in the well‐appearing febrile young infant. Data from references [22, 25, 49, 50]

From: Facing the ongoing challenge of the febrile young infant

Test Indications Potential role in management
RSV testing Infants with respiratory symptoms If positive, may safely avoid LPs, antibiotic exposure, and hospitalizations
EV testing Infants undergoing LP and CSF studies If positive, may consider discontinuing antibiotics, discharge home if bacterial cultures negative at 24–36 h
Influenza testing Infants with respiratory symptoms, especially during high regional prevalence If positive, may consider discontinuing antibiotics, discharge home if bacterial cultures negative at 24–36 h
Procalcitonin Otherwise low‐risk infants with negative virological testing If normal/minimal elevation: may consider initial inpatient observation off antibiotics, avoidance of LP, or outpatient management
  1. LP lumbar puncture, CSF cerebrospinal fluid, RSV respiratory syncytial virus, EV enterovirus