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Table 1 Effect of critical illness and extracorporeal membrane oxygenation (ECMO) on pharmacokinetics (PK) of drugs, based on degree of lipophilicity

From: Medicating patients during extracorporeal membrane oxygenation: the evidence is building

  Hydrophilic drugs Lipophilic drugs
Volume of distribution (Vd) Low High
Primary mode of clearance Renal Hepatic
Log P Low High
Potential effect of critical illness on PK Increased Vd No change in Vd
Effect of ECMO on PK Increased Vd Increased Vd
No change in clearance Increased clearance
  1. Log P: octanol‐water partition coefficient (measure of drug’s lipophilicity)