Table 1 Effect of critical illness and extracorporeal membrane oxygenation (ECMO) on pharmacokinetics (PK) of drugs, based on degree of lipophilicity
From: Medicating patients during extracorporeal membrane oxygenation: the evidence is building
Hydrophilic drugs | Lipophilic drugs | |
|---|---|---|
Volume of distribution (Vd) | Low | High |
Primary mode of clearance | Renal | Hepatic |
Log P | Low | High |
Potential effect of critical illness on PK | Increased Vd | No change in Vd |
Effect of ECMO on PK | Increased Vd | Increased Vd |
No change in clearance | Increased clearance |