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Table 1 Haemodynamic variables in the control group and both SATI groups

From: Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

  

0 h

1 h

2 h

4 h

6 h

8 h

12 h

16 h

20 h

24 h

P value

HR bpm

CO

118 ± 22

126 ± 24

159 ± 20

158 ± 22

148 ± 20

144 ± 15

142 ± 16

146 ± 19

154 ± 23

155 ± 10

0.741*

LD SATI

127 ± 9

137 ± 18

160 ± 11

157 ± 16

151 ± 16

154 ± 14

148 ± 10

150 ± 21

143 ± 17

147 ± 19

0.593#

HD SATI

128. ±26

140 ± 20

158 ± 22

148 ± 20

144 ± 15

161 ± 16

155 ± 15

153 ± 19

157 ± 22

157 ± 22

0.263§

MAP mmHg

CO

114 ± 18

113 ± 19

103 ± 15

110 ± 12

125 ± 10

121 ± 22

115 ± 12

90 ± 20

74 ± 12

73 ± 6

0.591*

LD SATI

122 ± 13

125 ± 11

102 ± 15

112 ± 12

114 ± 11

121 ± 14

116 ± 16

102 ± 25

97 ± 23

100 ± 13

0.984#

HD SATI

114 ± 32

115 ± 14

98 ± 11

100 ± 13

112 ± 14

112 ± 18

110 ± 17

106 ± 20

91 ± 22

91 ± 22

0.534§

MPAP mmHg

CO

15 ± 3

15 ± 4

17 ± 3

17 ± 6

23 ± 5

23 ± 2

30 ± 6

34 ± 6

27 ± 6

24 ± 6

0.993*

LD SATI

14 ± 4

14 ± 3

15 ± 3

18 ± 4

20 ± 3

22 ± 4

32 ± 6

34 ± 6

29 ± 5

28 ± 5

0.687#

HD SATI

15 ± 2

15 ± 2

16 ± 2

18 ± 3

21 ± 3

22 ± 4

25 ± 6

27 ± 6

25 ± 5

26 ± 5.

0.780§

PAOP mmHg

CO

6 ± 3

6 ± 2

6 ± 2.

6 ± 2

5 ± 3

6 ± 2

5 ± 2

6 ± 2

5 ± 2

7 ± 2

0.895*

LD SATI

6 ± 2

7 ± 2

6 ± 1

5 ± 1

6 ± 1

6 ± 2

5 ± 1

6 ± 2

5 ± 2

5 ± 1

0.162#

HD SATI

6 ± 2

6 ± 1

6 ± 2

4 ± 1

4 ± 1

5 ± 1

4 ± 1

5 ± 1

4 ± 1

4 ± 1

0.374§

SVRI dyn/sec/cm-5

CO

3477 ± 1190

2658 ± 763

2036 ± 418

3023 ± 1177

3987 ± 841

4797 ± 1618

4656 ± 1514

3080 ± 994

2246 ± 869.1

1817 7 ± 761

1.00*

LD SATI

3445 ± 1198

2958 ± 885

2284 ± 717

2834 ± 619

2913 ± 612

3349 ± 673

3600 ± 826

3149 ± 761

2701 ± 600

2495 ± 589

0.318#

HD SATI

2873 ± 860

2366 ± 418

1856 ± 270

2258 ± 313

2587 ± 437

2646 ± 484

2480 ± 547

2548 ± 734

2034 ± 518

2034 ± 518

0.368§

PVRI dyn/sec/cm-5

CO

273 ± 125

240 ± 119

207 ± 81

346 ± 294

610 ± 291

705 ± 235.1

1011 ± 323

989 ± 368

639 ± 234

445 ± 238

0.855*

LD SATI

241 ± 125

178 ± 44

207 ± 50

322 ± 99

361 ± 73

449 ± 112.4

883 ± 342

1002 ± 501.9

717 ± 297

576 ± 168

0.324#

HD SATI

236 ± 58

195 ± 35

204 ± 44

337 ± 77

403 ± 235

424 ± 111

470 ± 158

558 ± 189

511 ± 177

512 ± 177

0.657§

CI L/min/m2

CO

2.8 ± 1.1

3.5 ± 1.1

4.3 ± 1.3

3.1 ± 0.9

2.5 ± 0.5

2.1 ± 0.7

2.1 ± 0.7

2.5 ± 0.9

2.9 ± 1.1

3.5 ± 1.2

0.828*

LD SATI

2.9 ± 0.8

3.6 ± 0.8

3.6 ± 0.8

3.1 ± 0.5

3.1 ± 0.5

2.9 ± 0.5

2.6 ± 0.5

2.6 ± 0.8

2.9 ± 0.8

3.2 ± 0.7

0.90#9

HD SATI

3.1 ± 0.6

3.8 ± 0.6

4.1 ± 0.6

3.5 ± 0.7

3.5 ± 0.8

3.4 ± 0.8

3.5 ± 0.7

3.3 ± 0.5

3.6 ± 0.9

3.6 ± 0.9

0.622§

Base excess mmol/L

CO

4.1 ± 2.0

0.9 ± 2.6

1.4 ± 2.0

-0.9 ± 2.5

-0.9 ± 3.0

-2.0 ± 2.8

-7.4 ± 3.3

-9.3 ± 3.9

-12.8 ± 4.8

-13.9 ± 6.0

0.024*

LD SATI

2,5 ± 4.3

0.8 ± 2.2

-0.9 ± 2.1

-1,5 ± 1.6

-2.1 ± 1.9

-2.3 ± 2.3

-3.8 ± 3.2

-7.4 ± 7.1

-7.3 ± 6.4

-3.7 ± 2.0

0.148#

HD-SATI

2.8 ± 2.0

-1.0 ± 2.4

-0.7 ± 2.2

-1.0 ± 2.8

-2.6 ± 2.2

-1.8 ± 2.9

-4.3 ± 2.8

-4.1 ± 2.4

-6.1 ± 3.3

-6.1 ± 4.9

0.655§

  1. Values are presented as mean and SD. HR heart rate, MAP mean artery pressure, MAPA mean pulmonary artery pressure, PACP pulmonary artery occlusion pressure, SVRI systemic vascular resistance index; pulmonary vascular resistance index; CI cardiac index, CO control group, HD-SATI, high-dose activated factor II and activated factor X inhibitor group; LD-SATI, high-dose activated factor II and activated factor X inhibitor group. P values are given for between-subjects analysis: *control vs LD-SATI; #control vs HD-SATI; §LD-SATI vs HD-SATI