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Fig. 5 | Critical Care

Fig. 5

From: Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

Fig. 5

a-f Inflammatory cytokines starting from baseline (time point 0) until the end of the experiment (time point 24 h). Arrow represents the duration of E. coli infusion (first 2 h). White control group (CO), light gray low-dose short-acting thrombosis inhibitor (LD-SATI), dark gray high-dose (HD)-SATI. SATI prevented increase in interleukin 6 (IL-6) release in both treatment groups. CO vs LD-SATI group ***p < 0.001, **p < 0.01, *p < 0.05; CO vs HD-SATI # # # p < 0.001, # # p < 0.01, # p < 0.05; no indication = not significant. Two-factor analysis of variance was used for between-group comparisons. Gray arrow represents the time of E. coli infusion. TNF-α tumor necrosis factor alpha, AT III antithrombin III, APC active protein C, TFPI tissue factor pathway inhibitor, TAFI thrombin-activated fibrinolysis inhibitor antigen, PAI-I plasminogen activator inhibitor 1 antigen

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Critical Care

ISSN: 1364-8535