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Fig. 2 | Critical Care

Fig. 2

From: Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

Fig. 2

a-c Thrombin-antithrombin complexes (TAT), fibrinogen (Fib) concentration and platelet count starting from baseline (time point 0 h) until the end of the experiment (time point 24 h). Arrow represents the duration of E. coli infusion (first 2 h). White control group (CO), light gray low-dose short-acting thrombosis inhibitor (LD-SATI), dark gray high-dose (HD)-SATI. SATI prevented TAT formation and consumption of fibrinogen but the decrease in platelet count was unaffected. a TAT. b Fibrinogen CO vs LD-SATI ***p < 0.001, **p < 0.01, *p < 0.05; CO vs HD-SATI ### p < 0.001, ## p < 0.01, # p < 0.05; no indication = not significant. Two-factor analysis of variance was used for between-group comparisons. Gray arrow represents the time of the E. coli infusion

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Critical Care

ISSN: 1364-8535