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Table 3 Association between acute kidney injury and the polymorphisms studied in 653 patients with sepsis (additive genetic model)

From: Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock

     

Univariate

Multivariate

SNP

Chr

Base-pair position

Gene and alleles (major/minor)

Minor allele frequencya

Odds ratio

(95% CI)

P value

Odds ratio

(95% CI)b

P value

rs625145

11

116857220

SIK3 A/T

0.20/0.21

0.88 (0.67–1.17)

0.38

0.93 (0.68–1.25)

0.62

rs1955656

14

94579038

SERPINA5 G/A

0.10/0.12

0.77 (0.53–1.10)

0.15

0.75 (0.51–1.10)

0.14

rs2093266

14

94566450

SERPINA4 G/A

0.10/0.12

0.77 (0.53–1.10)

0.15

0.75 (0.51–1.10)

0.14

rs8094315

18

63268814

BCL2 A/G

0.24/0.22

1.10 (0.85–1.43)

0.48

1.08 (0.81–1.43)

0.61

rs12457893

18

63258928

BCL2 A/C

0.37/0.37

1.02 (0.81–1.29)

0.87

1.06 (0.82–1.36)

0.67

  1. aPatients/controls. bAdjusted for age, body mass index, diabetes mellitus, mechanical ventilation, minimum platelet count, use of non-steroidal anti-inflammatory drugs as daily medication, chronic pulmonary obstructive disease, administration of contrast medium prior to ICU admission, administration of colloids prior to ICU admission, simplified acute physiology score II without age or renal components, operative admission, and source of infection. SNP single nucleotide polymorphism, Chr chromosome
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Critical Care

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